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Annals of Emergency Medicine
Volume 56, Issue 2
, Pages 105-113.e5
, August 2010
The Effect of a Bolus Dose of Etomidate on Cortisol Levels, Mortality, and Health Services Utilization: A Systematic Review
References
- . Manual of Emergency Airway Management. 2nd ed.. Philadelphia, PA: Lippincott Williams & Wilkins; 2004;
- . A review of etomidate for rapid sequence intubation in the emergency department. J Emerg Med. 1997;15:221–230
- . Should we use etomidate as an induction agent for endotracheal intubation in patients with septic shock? (a critical appraisal). Chest. 2005;127:1031–1038
- Etomidate versus midazolam for out-of-hospital intubation: a prospective, randomized trial. Ann Emerg Med. 2006;47:525–530
- Etomidate and thiopental-based anesthetic induction: comparisons between different titrated levels of electrophysiologic cortical depression and response to laryngoscopy. J Clin Anesth. 1997;9:36–41
- Cardiodynamic effects of propofol in comparison with thiopental: assessment with a transesophageal echocardiographic approach. Anesth Analg. 1991;72:28–35
- . Should etomidate be the induction agent of choice for rapid sequence intubation in the emergency department?. Emerg Med J. 2004;21:655–659
- . Etomidate revisited. Curr Opin Anaesthesiol. 1998;11:391–398
- Etomidate use during emergency intubation of trauma patients. Am J Emerg Med. 1997;15:98–100
- . Etomidate and intensive care physicians. Intensive Care Med. 2005;31:1454
- . ICU physicians should abandon the use of etomidate!. Intensive Care Med. 2005;31:325–326
- . Corticosteroids for patients with septic shock. JAMA. 2003;289:43–44
- . Etomidate as an induction agent for endotracheal intubation in patients with sepsis. Ann Emerg Med. 2009;53:406
- . Etomidate: not worth the risk in septic patients. Ann Emerg Med. 2009;52:15–16
- . Continue to use etomidate for intubation of patients with septic shock. Ann Emerg Med. 2008;52:13–14
- . Etomidate as an induction agent for endotracheal intubation in patients with sepsis. Ann Emerg Med. 2009;53:406
- . Corticosteroids for septic shock. N Engl J Med. 2008;358:2070
- Adrenal function in sepsis: the retrospective CORTICUS cohort study. Crit Care Med. 2007;35:1012–1018
- . Etomidate, sepsis, and adrenal function: not as bad as we thought?. Crit Care. 2007;11:145–146
- Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002;288:862–871
- Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358:111–124
- Etomidate and adrenocortical function. Lancet. 1883;321:1434
- . Influence of sedation on mortality in critically ill multiple trauma patients. Lancet. 1983;321:1270
- Adrenocortical suppression in multiply injured patients: a complication of etomidate treatment. Br Med J. 1983;287:1835–1837
- . The inhibition by etomidate of the 11 beta-hydroxylation of cortisol. Clin Endocrinol. 1984;20:625–629
- . Mortality amongst multiple trauma patients admitted to an intensive therapy unit. Anaesthesia. 1984;39:973–981
- Effect of a single bolus of etomidate upon eight major corticosteroid hormones and plasma ACTH. Clin Endocrinol. 1985;22:281–286
- Adrenocortical suppression by a single induction dose of etomidate. Klin Wochenschr. 1984;62:1014–1017
- Effects of etomidate on adrenocortical function. Acta Endocrinol. 1984;105:115
- Effect of an introductory dose of etomidate, methohexital and midazolam on adrenal cortex function before and after ACTH-stimulation. Dtsch Med Wochenschr. 1985;110:750–752
- . Effect of etomidate on cortisol biosynthesis: site of action after induction of anaesthesia. Acta Endocrinol. 1985;110:526–531
- The effect of anaesthetic induction with etomidate on the endocrine response to surgical trauma. Eur J Anaesthesiol. 1985;2:285–290
- Effects of etomidate on hormonal responses to surgical stress. Anesthesiology. 1984;61:652–656
- . Dual effect of etomidate on mineralocorticoid biosynthesis. Acta Anaesthesiol Belg. 1988;39:87–94
- . Effect on plasma cortisol concentrations of a single induction dose of etomidate or thiopentone. Lancet. 1983;2:625
- . Etomidate inhibits adrenocortical function in surgical patients. Anesthesiology. 1984;61:647–651
- . Etomidate versus thiopental: comparative effects on adrenocortical function. Anesthesiology. 1984;61:A353
- Inhibition of adrenal steroidogenesis by the anesthetic etomidate. N Engl J Med. 1984;310:1415–1421
- Etomidate infusion and adrenocortical function (A study in elective surgery). Acta Anaesthesiol Scand. 1985;29:483–485
- Adrenal insufficiency in meningococcal sepsis: bioavailable cortisol levels and impact of interleukin-6 levels and intubation with etomidate on adrenal function and mortality. J Clin Endocrinol Metab. 2005;90:5110–5117
- The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med. 2009;35:1868–1876
- Risk factors of relative adrenocortical deficiency in intensive care patients needing mechanical ventilation. Intensive Care Med. 2005;31:388–392
- Does the sedative agent facilitate emergency rapid sequence intubation?. Acad Emerg Med. 2003;10:612–620
- . Current controlled trials. http://www.controlled-trials.comAccessed November 25, 2007
- . The National Research Register (Update software). http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_4075210Accessed November 20, 2007
- . ClinicalTrails.gov http://clinicaltrials.govAccessed November 21, 2007
- Adrenal suppression following a single dose of etomidate for rapid sequence induction: a prospective randomized study. J Trauma. 2008;65:573–579
- A prospective observational study of the effect of etomidate on septic patient mortality and length of stay. Acad Emerg Med. 2009;16:11–14
- Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet. 2009;374:293–300
- Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials. 1996;17:1–12
- Meta-analysis of observational studies in epidemiology: a proposal for reporting (Meta-analysis of Observational Studies in Epidemiology (MOOSE) group). JAMA. 2000;283:2008–2012
- Variance imputation for overviews of clinical trials with continuous response. J Clin Epidemiol. 1992;45:769–773
- Propofol causes more hypotension than etomidate in patients with severe aortic stenosis: a double-blind, randomized study comparing propofol and etomidate. Acta Anaesthesiol Scand. 2007;51:284–289
- . Adrenocortical function in critically ill patients 24 h after a single dose of etomidate. Anaesthesia. 1999;54:861–867
- . Hormonal effects of an induction dose of etomidate for patients undergoing urgent myocardial revascularization. J Cardiothorac Anesth. 1988;2:171–176
- Perioperative response of leptin and the tumor necrosis factor alpha system in morbidly obese patients (Influence of cortisol inhibition by etomidate). Acta Anaesthesiol Scand. 2001;45:207–212
- Lipid kinetics in obese patients undergoing laparoscopy (The impact of cortisol inhibition by etomidate). Eur J Drug Metab Pharmacokinet. 2004;29:187–192
- . Adrenocortical dysfunction following etomidate induction in emergency department patients. Acad Emerg Med. 2001;8:1–7
- . Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock. Crit Care. 2007;11:1–8
- . Noninferiority trials. Curr Control Trials Cardiovasc Med. 2000;1:19–21
Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article that might create any potential conflict of interest. The authors have stated that no such relationships exist. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. This work was supported by a grant from the Vancouver Coastal Health Research Institute In It for Life fund. During the study period, Dr. Corinne Hohl was supported by a Mentored Clinician Scientist award from the Vancouver Coastal Health Research Institute.
Supervising editor: Kathy J. Rinnert, MD, MPH
Reprints not available from the authors.
Publication date: Available online March 25, 2010.
PII: S0196-0644(10)00103-4
doi: 10.1016/j.annemergmed.2010.01.030
© 2009 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.
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Annals of Emergency Medicine
Volume 56, Issue 2
, Pages 105-113.e5
, August 2010
