Annals of Emergency Medicine
Volume 56, Issue 3 , Pages 278-282 , September 2010

Therapeutic Efficacy of Icatibant in Angioedema Induced by Angiotensin-Converting Enzyme Inhibitors: A Case Series

  • Murat Bas, MD

      Affiliations

    • Hals-, Nasen- und Ohrenklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
    • Corresponding Author InformationAddress for correspondence: Murat Bas, MD, Hals-Nasen-Ohrenklinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, D-81675 Munich, Germany; 49-89-4140-2370, fax 49-89-4140-4853
    • ,
  • Jens Greve, MD

      Affiliations

    • Department of Otorhinolaryngology, University of Essen, Essen, Germany
    • ,
  • Klaus Stelter, MD

      Affiliations

    • Department of Otorhinolaryngology, University of Munich, Munich, Germany
    • ,
  • Henning Bier, MD

      Affiliations

    • Hals-, Nasen- und Ohrenklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
    • ,
  • Thomas Stark, MD

      Affiliations

    • Hals-, Nasen- und Ohrenklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
    • ,
  • Thomas K. Hoffmann, MD

      Affiliations

    • Department of Otorhinolaryngology, University of Essen, Essen, Germany
    • ,
  • Georg Kojda, PharmD, PhD

      Affiliations

    • Institute of Pharmacology and Clinical Pharmacology, University of Duesseldorf, Dusseldorf, Germany

Received 27 September 2009 ,Revised 8 February 2010 ,Accepted 22 March 2010.

References 

  1. Yusuf S, Teo K, Anderson C, et al. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial. Lancet. 2008;372:1174–1183
  2. Bas M, Adams V, Suvorava T, et al. Non-allergic angioedema (Role of bradykinin). Allergy. 2007;62:842–856
  3. Pfeffer MA, McMurray JJ, Velazquez EJ, et al. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med. 2003;349:1893–1906
  4. Bas M, Hoffmann TK, Bier H, et al. Increased C-reactive protein in ACE-inhibitor-induced angioedema. Br J Clin Pharmacol. 2005;59:233–238
  5. Nussberger J, Cugno M, Amstutz C, et al. Plasma bradykinin in angio-oedema. Lancet. 1998;351:1693–1697
  6. Bork K, Frank J, Grundt B, et al. Treatment of acute edema attacks in hereditary angioedema with a bradykinin receptor-2 antagonist (icatibant). J Allergy Clin Immunol. 2007;119:1497–1503
  7. Han ED, MacFarlane RC, Mulligan AN, et al. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J Clin Invest. 2002;109:1057–1063
  8. Davis AE. Biological effects of C1 inhibitor. Drug News Perspect. 2004;17:439–446
  9. Davis AE, Bissler JJ, Cicardi M. Mutations in the C1 inhibitor gene that result in hereditary angioneurotic edema. Behring Inst Mitt. 1993;93:313–320
  10. Davis AE. The pathogenesis of hereditary angioedema. Transfus Apher Sci. 2003;29:195–203

 Please see page 279 for the Editor's Capsule Summary of this article.

 Supervising editor: Richard C. Dart, MD, PhD

 Author contributions: MB, JG, and KS defined the research theme. MB, HB, TKH, and GK designed the methods and study design, analyzed the data, interpreted the results, and wrote the article. TS assisted with associated data collection and their interpretation. All authors have contributed to, seen, and approved the article. MB takes responsibility for the paper as a whole.

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article that might create any potential conflict of interest. The authors have stated that no such relationships exist. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement.

 Publication date: Available online May 5, 2010.

 Reprints not available from the authors.

PII: S0196-0644(10)00279-9

doi: 10.1016/j.annemergmed.2010.03.032

Annals of Emergency Medicine
Volume 56, Issue 3 , Pages 278-282 , September 2010

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