Annals of Emergency Medicine
Volume 30, Issue 1 , Pages 33-39 , July 1997

Affinity-Purified, Mixed Monospecific Crotalid Antivenom Ovine Fab for the Treatment of Crotalid Venom Poisoning

Received 14 October 1996 ,Revised 7 April 1997 ,Accepted 11 April 1997.

References 

  1. Russell FE. Snake Venom Poisoning. In: Great Neck, NY: Scholium International; 1983;p. 268
  2. Jurkovich GJ, Luterman A, McCullar K, et al.  Complications of Crotalidae antivenin treatment. J Trauma. 1988;28:1032–1037
  3. Corrigan P, Russell FE, Wainschel J. Clinical reactions to antivenin. Toxicon. 1978;(suppl):457–465
  4. Sullivan JB, Russell FE. Isolation and purification of antibodies to rattlesnake venom by affinity purification. Proc West Pharmacol Soc. 1982;25:185–189
  5. Sullivan JB, Russell FE. Isolation, quantitation, and subclassing of IgG antibody to Crotalidae venom by affinity chromatography and protein electrophoresis. Toxicon. 1983;3(suppl):429–432
  6. Antman EM, Wenger TL, Butler VP, et al.  Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. Circulation. 1990;81:1744–1752
  7. Kirkpatrick CH. Allergic histories and reactions of patients treated with digoxin immune Fab (ovine) antibody. Am J Emerg Med. 1991;9(suppl 1):7–10
  8. Consroe P, Egen NB, Russell RE, et al.  Comparison of a new ovine antigen binding fragment (Fab) for United States Crotalidae with the commercial antivenin for protection against venom-induced lethality in mice. Am J Trop Med Hyg. 1995;53:507–510
  9. Dart RC, Hurlbut KM, Garcia R, et al.  Validation of a severity score for the assessment of crotalid snakebite in the United States. Ann Emerg Med. 1996;27:321–326
  10. Lindsey D. Controversy in snakebite: Time for a controlled appraisal. J Trauma. 1985;25:462–463
  11. Smith TW, Butler VP, Haber E, et al.  Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments: Experience in 26 cases. N Engl J Med. 1982;307:1357–1362
  12. Schaumann W, Kaufmann B, Neubert P, et al.  Kinetics of the Fab fragments of digoxin antibodies and of bound digoxin in patients with severe digoxin intoxication. Eur J Clin Pharmacol. 1986;30:527–533
  13. Burgess JL, Dart RC, Egen NB, et al.  Effects of constriction bands on rattlesnake venom absorption: A pharmacokinetic study. Ann Emerg Med. 1992;21:1086–1093
  14. Hurlbut KM, Dart RC, Spaite D, et al.  Reliability of clinical presentation for predicting significant pit viper envenomation. [abstract] Ann Emerg Med. 1988;17:438–439
  15. Ho M, Warrell MJ, Warrell DA, et al.  A critical reappraisal of the use of enzyme-linked immunosorbent assays in the study of snake bite. Toxicon. 1986;24:211–221

☆ From the Rocky Mountain Poison and Drug Center, Denver Health,* and the University of Colorado Health Sciences Center,‡ Denver, CO; the Department of Emergency Medicine, Kino Community Hospital,§ and the Departments of Pediatrics∥ and Clinical Medicine, University of Arizona College of Medicine, Tucson, AZ; the Department of Medical Toxicology, Good Samaritan Regional Medical Center,# Phoenix, AZ; the San Diego Regional Poison Center** and the University of California,‡‡ San Diego, CA; John D Archbold Memorial Hospital, Thomasville, GA;§§ and the Veterans Administration Hospital, Gainesville, FL.∥∥

☆☆ Supported by US Food and Drug Administration Orphan Product Development grant FD-R-000945-01-1.

★ Reprint no. 47/1/82666

★★ Address for reprints: Richard C Dart, MD, PhD, Rocky Mountain Poison and Drug Center, 8802 East Ninth Avenue, Denver, CO 80220, 303-739-1100, Fax 303-739-1119, E-mail dartr@usa.net

PII: S0196-0644(97)70107-0

Annals of Emergency Medicine
Volume 30, Issue 1 , Pages 33-39 , July 1997

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