| | Cardiology and emergency medicine: United We Stand, divided we fall☆
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Persistence of delays in presentation and treatment for patients with acute myocardial infarction: The GUSTO-I and GUSTO-III experience
W.Brian Gibler, Paul W. Armstrong, E.Magnus Ohman, W.Douglas Weaver, Amanda L. Stebbins, Joel M. Gore, L.Kristin Newby, Robert M. Califf, Eric J. Topol, For the Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) Investigators
Annals of Emergency Medicine
February 2002 (Vol. 39, Issue 2, Pages 123-130)
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Abstract [Gibler WB, Topol EJ, Holroyd B, Armstrong PW. Cardiology and emergency medicine: united we stand, divided we fall.Ann Emerg Med. February 2002;39:164-167.]
See related article, p. 123 .
The explosive growth of cardiovascular medicine in the past quarter century and the burgeoning number of patients presenting with acute chest pain and possible acute coronary syndromes (ACS) have focused the issue of delivery of high-quality patient care squarely on the interface between cardiology and emergency medicine. Hence, it is our intention in this paper to explore the relationship between these 2 disciplines, especially regarding patients with ACS, and to suggest a template for enhancing future collaborations in education, research, and patient care.
Evolution of care for ACS  Since the early 1960s, emergency cardiovascular care has enjoyed phenomenal growth in monitoring, diagnostics, and therapy.1, 2, 3, 4 For the diagnosis and treatment of ACS, care has progressed from passive monitoring for cardiac dysrhythmias in the coronary care unit to the current aggressive strategies that include serial 12-lead ECG surveillance, serial troponin testing, antithrombin and glycoprotein IIb/IIIa receptor inhibitor infusion, fibrinolytic therapy, and percutaneous coronary intervention.5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 Through these advances, mortality resulting from acute myocardial infarction (AMI) has decreased from nearly 20% to its current level of approximately 6%. Collaboration between the disciplines of emergency medicine and cardiology has resulted in better coordinated approaches to patients with ACS.19
Traditional cardiology collaboration  In the past, cardiologists have traditionally developed collaborative partnerships with “in-hospital” disciplines such as internal medicine, cardiac surgery, and radiology. Over the past 2 decades, research protocols and the development of clinical care guidelines have emphasized that, for optimal care to be delivered in patients with ACS, and AMI in particular, rapid diagnosis and correct treatment must be initiated as promptly as possible in the emergency department or even in the out-of-hospital environment.10, 11 Cardiologists and emergency physicians in many hospitals in North America found that protocol development required effective, continuing communication with the principals and their staff to ensure reproducible, efficient, evidence-based approaches to patients with ACS presenting to the ED. It is most desirable to see this model develop in an atmosphere of mutual respect and cordiality, in which the differing perspectives and knowledge base of the 2 specialties become aligned toward the common goal of optimal patient care.
Previous successful ventures  Several examples of successful collaboration between the specialties of cardiology and emergency medicine have emerged over the last decade. In the early 1990s, the use of fibrinolytic therapy for patients with AMI was successfully transitioned from cardiologists to emergency physicians. Multiple placebo-controlled trials using fibrinolytic therapy for AMI in the second half of the 1980s revealed the time dependency of this therapy. Patients treated within the first hours after symptom onset were found to derive the greatest benefit.10 For patients with AMI to receive this early treatment benefit, it became clear that fibrinolytic therapy would have to be given in the ED. Emergency cardiac care specialists from emergency medicine and cardiology subsequently concluded in a cooperative directive from the National Heart Attack Alert Program that patients with AMI ideally should receive therapy within 30 minutes after hospital presentation. It was the understanding of this committee that emergency physicians would need to rapidly identify and treat these patients in the emergency setting if this 30-minute goal was to be accomplished. The highly successful approach to AMI therapy, defined as the 4 “Ds”: door, data, decision, and drug, resulted from this collaboration between cardiology and emergency medicine.11 In a similar fashion, the coordination of efforts between the 2 specialties has recently been established for ACS through the development of the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the ACC/AHA Guidelines (CRUSADE) Quality Improvement Initiative. With the co-chairs and Steering Committee equally balanced between emergency medicine and cardiology, the CRUSADE Quality Improvement Initiative is designed to support the 2000 American College of Cardiology and American Heart Association guidelines for the care of patients with ACS.20, 21 This effort should ensure that patients with ACS receive optimal care that is evidence-based. Although these 2 examples represent outstanding cooperation between the 2 disciplines, further efforts are necessary to enhance the care of patients with ACS presenting to the emergency setting of every hospital. Scarce resources, competition for research funding and academic recognition, concern for litigation, and increasingly complex patient groups and treatment options can generate tension across this rapidly moving field, placing a high priority on cordial communication and teamwork.
The evolution of the emergency department in appraising chest pain  The ED in most hospitals in North America now serves as a major diagnostic and treatment center that focuses on the timely, effective triage of patients with ACS. This consists of rapid hospital admission of patients with severe or critical illness, discharge of patients at low risk with appropriate follow-up, and the release of still other patients after extensive diagnostic evaluations and treatment that prevents hospital admission. In the current environment of managed care, increasing patient visits to the ED, fewer in-patient beds for those requiring admission, and more time-consuming and sophisticated workups for all patients, caring for the patient with possible ACS is an even greater challenge. The burden of enormous amounts of diagnostic and therapeutic clinical trial information for ACS, combined with severe overcrowding of ED beds, can confound any clinician aiming to make rapid and accurate decisions for the patient presenting with possible ACS. For these reasons, cardiologists and emergency physicians at every hospital should seek to develop an evidence-based approach for the care of patients with ACS. This can be facilitated with contemporary information technology and the use of risk models and treatment guidelines. With this paradigm, every patient coming to the hospital with possible ACS will have an efficient, consistent diagnostic evaluation for risk stratification and clearly defined treatment protocols that emphasize timely, safe treatment. Chest pain centers modeled after trauma centers have recently been developed in many EDs to facilitate such care.22
Preparing for other cardiologic advances  Whereas our paper has emphasized advances made in ACS diagnosis and treatment, substantial progress has been made in other emergency cardiac care arenas. Technological growth in pacemakers, defibrillators, and complex physiologic and electrical monitoring, as well as increased understanding in disease processes such as congestive heart failure, cardiac transplant emergencies, atrial and ventricular arrhythmias, and cardiac arrest, demand similar cooperation between emergency physicians and cardiologists to ensure optimal patient care.
Proposal  We propose the following approaches for education, clinical research, and patient care to optimize the collaboration between the specialties of emergency medicine and cardiology: Education of health care providers Explosive expansion of knowledge in ACS diagnosis and treatment is a challenge to all health care providers, including physicians, nurses, and paramedics. As the evidence basis grows for specific strategies, plans must be made to provide education at the individual practitioner, hospital, and national levels. Previously, education has been directed toward the medical student, resident-in-training, or continuing medical education physician learner. Although this approach is essential to developing care guidelines by cardiologists and emergency physicians, it does not include the individuals who will actually provide the care to the patient with ACS. Parallel development of comprehensive educational programs for emergency and critical care nurses, as well as for out-of-hospital care providers, will ensure that everyone on the care team understands and can execute an evidence-based diagnostic and treatment regimen for ACS. Clinical investigation The development of a close relationship between emergency medicine and cardiology must not be just a “downstream” incorporation of clinical discoveries into care plans. The important role of out-of-hospital care and emergency services in the diagnosis and rapid treatment of ACS necessitates the involvement of emergency physicians in clinical research initiatives at the development stage. To reach the next plateau in patient care, the disciplines of cardiology, emergency medicine, nursing, and out-of-hospital care providers should work together to develop optimal study design and establish clinical outcomes. Providing a high priority for collaborative emergency cardiac research at the level of study leadership can ensure that this will occur. Such a research team should include the development and maintenance of an appropriate research infrastructure and criteria for joint participation of cardiology and emergency medicine at all levels of steering committee involvement, including design and conduct of the trial, analysis and presentation of the data, and publication of the results. At the site level, creating the optimal climate, environment, and culture for research is often challenging given the unrelenting demands of clinical care. Aligning intellectual and financial incentives fairly between cardiology and emergency medicine and assigning appropriate co-investigatorship will encourage the collaboration and maximize high quality and quantity patient enrollment into clinical trials. Improving routine care In hospitals with excellent cooperation between our 2 specialties, integration of new scientific discoveries can be greatly improved. Ultimately, patients who are at high risk with ACS are likely to be identified initially in the out-of-hospital environment and treated with a combination of drugs strategically aimed at reducing the likelihood that the patient with a ruptured plaque will advance to full coronary occlusion on the one hand, or facilitating reperfusion on the other. Sophisticated monitoring by well-trained personnel with appropriate response devices should also be seamless, beginning at the patient's home and continuing to the ED, chest pain unit, catheterization laboratory, or coronary care unit. Without true collaboration between these health care providers, these advances cannot be realized. Creation of site-specific and multicenter databases Careful adherence to diagnostic and treatment pathways that are evidence-based allows every hospital to compare outcomes from month to month and from year to year. Continuous quality improvement can then be used to identify impediments to achieving optimal results. Linkage of registries from one individual hospital to multiple medical centers throughout North America can allow benchmarking of hospitals with the best results to be used by all participant hospitals. In many hospitals with healthy communication lines between cardiology and emergency medicine, such data can be the starting point for developing a collaboration that truly improves patient care and outcome. Such initiatives should emphasize commonality of definitions and end points. Subspecialization within emergency medicine and cardiology Finally, within the field of cardiology, subspecialization now includes electrophysiology, nuclear imaging, echocardiography, and acute intervention. Toxicology, emergency medical services (out-of-hospital care), and pediatric emergency medicine represent areas of fellowship preparation in emergency medicine. A sufficient body of knowledge now exists in ACS to develop subspecialization for cardiology and emergency medicine. Fellowship training in ACS should be provided within cardiology and emergency medicine to develop specialists who have the expertise to design and implement future trials that can provide important new information for this dynamic field. Fellowship-trained physicians in ACS from cardiology and emergency medicine could then collaborate to ensure that research and clinical care reflects the input of the 2 disciplines. It is clear to us that future progress in the care, teaching, and investigation of ACS is best achieved through enlightened partnerships. Cardiology and emergency medicine must surely stand united to advance our common goals and to continue progress in patient care.
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Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH Department of Cardiology,.The Cleveland Clinic Foundation, Cleveland, OH Department of Emergency Medicine, University of Alberta, Edmonton, Alberta Edmonton, Alberta, Canada Division of Cardiology Department of Medicine, University of Alberta, Edmonton, Alberta, Canada ☆ Address for reprints: W. Brian Gibler, MD, Department of Emergency Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0769; 513-558-8086, fax 513-558-4599; E-mail brian.gibler@uc.edu . PII: S0196-0644(02)29354-3 doi:10.1067/mem.2002.121469 © 2002 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved. | |
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