Annals of Emergency Medicine
Volume 39, Issue 2 , Pages 123-130 , February 2002

Persistence of delays in presentation and treatment for patients with acute myocardial infarction: The GUSTO-I and GUSTO-III experience

Received 12 June 2000 ,Revised 28 August 2001 ,Accepted 30 October 2001.

References 

  1. Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto miocardico GISSI . Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet. 1986;1:397–401
  2. Fibrinolytic Therapy Trialist's FTT Collaborative Group . Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomized trials of more than 1,000 patients. Lancet. 1994;343:311–322
  3. National Heart Attack Alert Program Coordinating Committee, 60 Minutes to Treatment Working Group . Rapid identification and treatment of acute myocardial infarction in the emergency department. Ann Emerg Med. 1994;23:311–329
  4. Rogers WJ, Bowlby LJ, Chandra N, et al.  Treatment of myocardial infarction in the United States (1990-1993). Circulation. 1994;90:2103–2114
  5. Newby LK, Rutsch WR, Califf RM, et al.  Time from symptom onset to treatment and outcomes after thrombolytic therapy. J Am Coll Cardiol. 1996;27:1646–1655
  6. The GUSTO Investigators . An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med. 1993;329:673–682
  7. The GUSTO III Investigators . A comparison of reteplase with alteplase for acute myocardial infarction. N Engl J Med. 1997;337:1118–1123
  8. Weaver WD. Time to thrombolytic treatment: factors affecting delay and their influence on outcome. J Am Coll Cardiol. 1995;25:35–95
  9. Rawles J. Halving of mortality at 1 year by domiciliary thrombolysis in the Grampian Region Early Anistreplase Trial (GREAT). J Am Coll Cardiol. 1994;23:1–5
  10. Weaver WD, Cerqueira M, Hallstrom AP, et al.  Prehospital-initiated versus hospital-initiated thrombolytic therapy. The Myocardial Infarction Triage and Intervention Trial. JAMA. 1993;270:1211–1216
  11. Malacrida R, Genoni M, Maggioni AP, et al.  A comparison of the early outcome of acute myocardial infarction in women and men. N Engl J Med. 1998;338:8–14
  12. Burnet RE, Blumenthal JA, Mark DB, et al.  Distinguishing between early and late responders to symptoms of acute myocardial infarction. Am J Cardiol. 1995;75:1019–1022
  13. Chaturvedi N, Rai H, Ben-Shlomo U. Lay diagnosis and health-care-seeking behavior for chest pain in South Asians and Europeans. Lancet. 1997;350:1578–1583
  14. Weaver WD, White HD, Wilcox RG, et al.  Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy. JAMA. 1996;275:772–782
  15. Cooper RS, Simmons B, Castaner A, et al.  Survival rates and prehospital delay during myocardial infarction among black persons. Am J Cardiol. 1986;57:208–211
  16. Chandra NC, Ziegelstein RC, Rogers WJ, et al.  Observations of the treatment of women in the United States with myocardial infarction. Arch Intern Med. 1998;158:981–988
  17. Lambrew CT, Bowlby LJ, Rogers WJ, et al.  Factors influencing the time to thrombolysis in acute myocardial infarction. Arch Intern Med. 1997;157:2577–2582
  18. Ho MT, Eisenberg MS, Litwin PE, et al.  Delay between onset of chest pain and seeking medical care: the effect of public education. Ann Emerg Med. 1989;18:727–731
  19. Luepker RV. Reducing prehospital patient related delays. In: Paper presented at: American Heart Association Meeting Plenary Session Dallas, TX. November 9, 1998;
  20. Kereiakes DJ, Weaver WD, Anderson JI, et al.  Time delays in the diagnosis and treatment of acute myocardial infarction: a tale of eight cities. Report from the Pre-hospital Study Group and the Cincinnati Heart Project. Am Heart J. 1990;120:773–780
  21. Gibler WB, Kereiakes DJ, Dean EN, et al.  Prehospital diagnosis and treatment of acute myocardial infarction: a North-South perspective. Am Heart J. 1991;121:1–11
  22. Schulman KA, Berlin JA, Harless W, et al.  The effect of race and sex on physicians' recommendations for cardiac catheterization. N Engl J Med. 1999;340:618–626
  23. Bayer AJ, Chadha JS, Farag RR, et al.  Changing presentation of myocardial infarction with increasing old age. J Am Geriatr Soc. 1986;34:263–266
  24. Margolis JR, Kannel WB, Feinlab M, et al.  Clinical features of unrecognized myocardial infarction: silent and asymptomatic. Eighteen-year follow-up: the Framingham Study. Am J Cardiol. 1973;32:1–7
  25. Magid DJ, Koepsell TD, Every NR, et al.  Absence of association between insurance copayments and delays in seeking emergency care among patients with myocardial infarction. N Engl J Med. 1997;336:1722–1729
  26. Sada MJ, French WJ, Carlisle DM, et al.  Influence of payer on use of invasive cardiac procedures and patient outcome after myocardial infarction in the United States. J Am Coll Cardiol. 1998;31:1474–1480
  27. Picken HA, Zucker DR, Griffith JL, et al.  Insurance type and the transportation to emergency departments of patients with acute cardiac ischemia: the ACI-TIPI trial insurance study. Am J Manag Care. 1998;821–827
  28. Pope JH, Aufderheide TP, Ruthazer R, et al.  Missed diagnoses of acute cardiac ischemia in the emergency department. N Engl J Med. 2000;342:1163–1170

☆ Author contributions are provided at the end of this article.

☆☆ Address for reprints: W. Brian Gibler, MD, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0769; 513-558-8086, fax 513-558-4599;,E-mail brian.gibler@uc.edu .

PII: S0196-0644(02)51793-5

doi: 10.1067/mem.2002.121402

Annals of Emergency Medicine
Volume 39, Issue 2 , Pages 123-130 , February 2002

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