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Annals of Emergency Medicine
Volume 44, Issue 4
, Pages 401-406
, October 2004
Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death
References
- Antidotes for Poisoning by Paracetamol. Cambridge, United Kingdom: Cambridge Press; 1995;
- . Mechanism of action and value of N-acetylcysteine in the treatment of early and late acetaminophen poisoning: a critical review. J Tox Clin Toxicol. 1998;36:277–285
- Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen poisoning. J Tox Clin Toxicol. 1999;37:759–767
- . Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med. 1998;31:710–715
- . Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning. Med J Aust. 1989;150:329–331
- . Adverse reactions to intravenous N-acetylcysteine in Chinese patients with paracetamol (acetaminophen) poisoning. Hum Exp Toxicol. 1994;13:542–544
- What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?. Ann Emerg Med. 2003;42:741–750
- . Clinical safety of high oral doses of acetylcysteine. Semin Oncol. 1983;10(Suppl 1):76–85
- Adverse reactions to acetylcysteine and effects of overdose. BMJ. 1984;289:217–219
- . Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning. Br J Clin Pharmacol. 2001;51:87–91
- . N-acetylcysteine overdosage after insignificant acetaminophen intake. [letter] Acta Paediatr. 2002;91:984–985
- . Death after N-acetylcysteine. [letter] Lancet. 1984;i:1421
- . Anaphylactoid response to intravenous acetylcysteine. [letter] Lancet. 1992;339:1231–1232
- . Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma. Emerg Med J. 2002;19:594–595
- . Adverse effects of intravenous N-acetylcysteine. [abstract] Vet Hum Toxicol. 1986;28:487
- . Les Antidotes en Toxicologie d'Urgence. Quebec, Canada: Centre Anti-poison du Québec; 1997;
- Status epilepticus following intravenous N-acetylcysteine therapy. Isr J Med Sci. 1996;32:1102–1104
- Hazards of therapy with high doses of N-acetylcysteine for anticonvulsant-induced hypersensitivity syndrome. [letter] Br J Dermatol. 1998;138:553
- . The toxicity of N-acetylcysteine in laboratory animals. Semin Oncol. 1983;10(Suppl 1):17–24
- . Status epilepticus: risk factors and complications. Epilepsia. 2000;41(Suppl 2):S23–S30
- Determinants of mortality in status epilepticus. Epilepsia. 1994;35:27–34
- . Status epilepticus. Ped Clin North Am. 2001;48:683–694
- . Prolonged epileptic seizures in primates. Arch Neurol. 1973;28:10–17
- . Status epilepticus. In: Rogers MC, Nichols DG editor. Textbook of Pediatric Intensive Care. Baltimore, MD: Williams and Wilkins; 1996;p. 747–777
- . Classification of status epilepticus. In: Delgado-Escueta AV, Wasterlain CG, Treiman DM, et al. editor. Advances in Neurology;. Status Epilepticus: Mechanisms of Brain Damage and Treatment. vol. 34:New York, NY: Raven Press; 1983;p. 15
- . Increased intracranial pressure associated with N-acetylcysteine inhalation therapy. [letter] Crit Care Med. 1984;12:926–927
- Random and systematic medication errors in routine clinical practice: a multicentre study of infusions, using acetylcysteine as an example. Br J Clin Pharmacol. 2001;52:573–577
- . Les Antidotes en Toxicologie d'Urgence. 2e édition. Quebec, Canada: Centre Anti-poison du Québec; 2002;
- Computerized physician order entry and medication errors in a pediatric critical care unit. Pediatrics. 2004;113:59–63
- . Effects of computerized physician order entry and clinical decision support systems on medication safety. Arch Intern Med. 2003;163:1409–1416
- . Serum N-acetylcysteine levels during hemodialysis. [abstract] Vet Hum Toxicol. 1992;34:327
The authors report this study did not receive any outside funding or support.
Reprints not available from the authors.
PII: S0196-0644(04)00545-1
doi: 10.1016/j.annemergmed.2004.05.014
© 2004 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.
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Annals of Emergency Medicine
Volume 44, Issue 4
, Pages 401-406
, October 2004
