Annals of Emergency Medicine
Volume 45, Issue 6 , Pages 595-602, June 2005

Crotalidae Polyvalent Immune Fab (Ovine) Antivenom Is Effective in the Neutralization of South American Viperidae Venoms in a Murine Model

From the Department of Emergency Medicine, Palmetto Richland Memorial Hospital, Palmetto Poison Center, Columbia, SC (Richardson); Department of Emergency Medicine, Naval Medical Center–San Diego, San Diego, CA (Tanen, Carstairs); Department of Emergency Medicine, Division of Medical Toxicology, University of California San Diego Medical Center, San Diego, CA (Tong, Betten, Williams, Clark); and the California Poison Control System–San Diego Division, San Diego, CA (Cantrell)

Received 30 April 2004; received in revised form 30 June 2004 and 25 August 2004; accepted 30 August 2004. published online 07 March 2005.

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 Author contributions: WHR and RFC conceived the study, design, and research. WHR and RFC obtained funding for the project. WHR coordinated data collection, analysis, and drafted the manuscript. WHR and RFC supervised the study and data collection. WHR, DAT, TCT, DPB, SDC, SRW, and FLC assisted with dosing trials, data collection, and modification of the study. WHR, DAT, SRW, and RFC participated in revision of the manuscript. WHR takes responsibility for the paper as a whole.Funding and support: Supported in part by an unrestricted grant from Altana, Inc. (Melville, NY) and antivenom donation from Protherics, Inc. (Nashville, TN).Presented at the Society of Academic Emergency Medicine annual meeting, Orlando, FL, May 2004.Reprints not available from the authors.

PII: S0196-0644(04)01324-1

doi:10.1016/j.annemergmed.2004.08.038

Annals of Emergency Medicine
Volume 45, Issue 6 , Pages 595-602, June 2005

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