Annals of Emergency Medicine
Volume 45, Issue 4 , Pages 402-408, April 2005

The Australasian Clinical Toxicology Investigators Collaboration Randomized Trial of Different Loading Infusion Rates of N-Acetylcysteine

From Austin Health, Studley Road, Heidelberg, Victoria, Australia (Kerr); the Department of Clinical Toxicology, Newcastle Mater Hospital, Newcastle, New South Wales, Australia (Dawson, Whyte); The Canberra Hospital, Canberra, Australian Capital Territory, Australia (Buckley); University of Western Australia, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia (Murray); Westmead Hospital, Sydney, New South Wales, Australia (Graudins); Emergency Medicine, Prince of Wales Hospital, Randwick, New South Wales, Australia (Chan); and CMAX, Institute of Drug Technology, Royal Adelaide Hospital, Adelaide, South Australia, Australia (Trudinger)

Received 17 May 2004; received in revised form 5 July 2004; accepted 31 August 2004. published online 09 February 2005.

SEE EDITORIAL, P. 409.

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 Author contributions: FK, AD, IMW, NB, LM, AG, and BC conceived the study, designed the trial, and helped obtain ethics approval in their respective centers. FK, AD, IMW, NB, LM, AG, and BC supervised the conduct of the trial and data collection. BT, AD, and IMW provided statistical advice on study design and helped analyze the data; FK drafted the manuscript, and all authors contributed substantially to its revision. All authors take responsibility for the paper as a whole.Funding and support: The research study was not financially supported. After data collection, the statistical analysis was performed by CMAX, Institute of Drug Technology, Adelaide, South Australia and paid for by Cumberland Pharma, Nashville, TN.

 Reprints not available from the authors.

PII: S0196-0644(04)01326-5

doi:10.1016/j.annemergmed.2004.08.040

Annals of Emergency Medicine
Volume 45, Issue 4 , Pages 402-408, April 2005

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