Annals of Emergency Medicine
Volume 45, Issue 3 , Pages 330-332 , March 2005

Do Corticosteroids Decrease Mortality in Sepsis?

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  2. Rivers E, Nguyen B, Havstad S, et al. for the Early Goal-Directed Therapy Collaborative Group Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368–1377
  3. Cronin L, Cook DJ, Carlet J, et al. Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature. Crit Care Med. 1995;23:1430–1439
  4. Lefering R, Neugebauer EAM. Steroid controversy in sepsis and septic shock: a meta-analysis. Crit Care Med. 1995;23:1294–1303
  5. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864–874
  6. Annane D, Bellissant E, Bollaert PE, et al. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ. 2004;329:480;Originally published online August 2, 2004. doi:10.1136/bmj.38181.482222.55
  7. Minneci P, Deans KJ, Banks SM, et al. Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Ann Intern Med. 2004;141:47–56
  8. Luce JM. Physicians should administer low-dose corticosteroids selectively to septic patients until an ongoing trial is completed. Ann Intern Med. 2004;141:70–72
  9. Hopewell S, McDonald S, Clarke M, et al. Grey literature in meta-analyses of randomized trials of health care interventions (The Cochrane Library). Issue 2. Chichester, United Kingdom: John Wiley & Sons, Ltd.; 2004;

PII: S0196-0644(04)01744-5

doi: 10.1016/j.annemergmed.2004.12.002

Annals of Emergency Medicine
Volume 45, Issue 3 , Pages 330-332 , March 2005

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