Annals of Emergency Medicine
Volume 46, Issue 4 , Pages 352-361 , October 2005

Randomized Double-Blind Trial Comparing Oral Paracetamol and Oral Nonsteroidal Antiinflammatory Drugs for Treating Pain After Musculoskeletal Injury

  • William W.K. Woo, FRCS(Edin), FHKAM
    • ,
  • Sin-Yan Man, FRCS(Edin), FHKAM
    • ,
  • Peggo K.W. Lam
    • ,
  • Timothy H. Rainer, MD, FHKAM

      Affiliations

    • Corresponding Author InformationAddress for reprints: Timothy H. Rainer, MD, FHKAM, Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Rooms 107/113, 1/F, Trauma and Emergency Center, Prince of Wales Hospital, Shatin, NT, Hong Kong; 852-2632-1033, fax 852-2648-1469

Received 15 June 2004 ,Revised 7 January 2005 ,Accepted 17 January 2005.

References 

  1. Leufkens HG, Ameling CB, Hekster YA, et al. Utilization patterns of non-steroidal anti-inflammatory drugs in an open Dutch population. Pharm Weekbl Sci. 1990;12:97–103
  2. McManus P, Primrose JG, Henry DA, et al. Pattern of non-steroidal anti-inflammatory drug use in Australia 1990-1994: a report from the drug utilization sub-committee of the pharmaceutical benefits advisory committee. Med J Aust. 1996;164:589–592
  3. British Medical Association . British National Formulary. London: British Medical Association and the Royal Pharmaceutical Society of Great Britain. 2002;
  4. Gotzsche PC. Non-steroidal anti-inflammatory drugs: the pendulum swings. BMJ. 2000;320:1058–1061
  5. Huskisson EC. Measurement of pain. Lancet. 1974;2:1127–1131
  6. Todd KH, Funk KG, Funk JP, et al. Clinical significance of reported changes in pain severity. Ann Emerg Med. 1996;27:485–489
  7. Hintze J. NCSS and PASS (2001): Number Cruncher Statistical Systems. Kaysville, UT: NSCC; 2001.
  8. Sleet RA, Khan MA. Comparative study of mefenamic acid and dextropropoxyphene plus paracetamol in an accident and emergency department. Curr Med Res Opin. 1980;7:77–84
  9. Palangio M, Morris E, Doyle RT, et al. Combination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of moderate or severe acute low back pain. Clin Ther. 2002;24:87–99
  10. Muncie HL, King DE, DeForge B. Treatment of mild to moderate pain of acute soft tissue injury: diflunisal versus acetaminophen with codeine. J Fam Pract. 1986;23:125–127
  11. Aghababian RV. Comparison of diflunisal and acetaminophen with codeine in the management of grade 2 ankle sprain. Clin Ther. 1986;8:520–526
  12. Indelicato PA. Comparison of diflunisal and acetaminophen with codeine in the treatment of mild to moderate pain due to strains and sprains. Clin Ther. 1986;8:269–274
  13. Indelicato PA. Efficacy of diflunisal versus acetaminophen with codeine in controlling mild to moderate pain after arthroscopy. Clin Ther. 1986;8:164–169
  14. Bakshi R, Rotman H, Shaw M, et al. Double blind, multicenter evaluation of the efficacy and tolerability of diclofenac dispersible in the treatment of acute soft-tissue injuries. Clin Ther. 1995;17:30–37
  15. Hoogewijs J, Diltoer MW, Hubloue I, et al. A prospective, open, single blind, randomized study comparing four analgesics in the treatment of peripheral injury in the emergency department. Eur J Emerg Med. 2000;7:119–123
  16. Lanza FL, Codispoti JR, Nelson EB. An endoscopic comparison of gastroduodenal injury with over-the-counter doses of ketoprofen and acetaminophen. Am J Gastroenterol. 1998;93:1020–1022

 Supervising editor: Knox H. Todd, MD, MPHAuthor contributions: TR had the idea for the study, obtained approval, and has overseen the entire planning, execution, analysis, and preparation of manuscript. He is guarantor of the work. WKW and SYM participated in the planning, execution, and analysis. PL and TR prepared the statistical analysis. TR wrote the first draft of the paper, and all authors have contributed to the final version. TR takes responsibility for the paper as a whole.Funding and support: The authors report this study did not receive any outside funding or support.

PII: S0196-0644(05)00099-5

doi: 10.1016/j.annemergmed.2005.01.023

Annals of Emergency Medicine
Volume 46, Issue 4 , Pages 352-361 , October 2005

Article Tools

* Image Usage & Resolution