Annals of Emergency Medicine
Volume 46, Issue 4 , Pages 362-367 , October 2005

Intravenous Morphine at 0.1 mg/kg Is Not Effective for Controlling Severe Acute Pain In the Majority of Patients

  • Polly E. Bijur, PhD

      Affiliations

    • Corresponding Author InformationAddress for correspondence: Polly E. Bijur, PhD, Albert Einstein College of Medicine, Rose F. Kennedy Center, 1410 Pelham Parkway South, Bronx, NY 10461; 718-430-4217, fax 718-430-8821
  • ,
  • Mark K. Kenny, PhD
  • ,
  • E. John Gallagher, MD

Received 15 December 2004 ,Revised 15 February 2005 ,Accepted 10 March 2005.

References 

  1. Brown JC, Klein EJ, Lewis CW, et al. Emergency department analgesia for fracture pain. Ann Emerg Med. 2003;42:197–205
  2. Todd KH. Emergency medicine and pain: a topography of influence. Ann Emerg Med. 2004;43:504–506
  3. Lasagna L, Beecher H. The optimal dose of morphine. JAMA. 1954;156:230–234
  4. Dahlstrom B, Tamsen A, Paalzow L, et al. Patient-controlled analgesic therapy, part IV: pharmacokinetics and analgesic plasma concentrations of morphine. Clin Pharmacokinet. 1982;7:266–279
  5. Aubrun F, Langeron O, Quesnel C, et al. Relationships between measurement of pain using visual analog score and morphine requirements during postoperative intravenous morphine titration. Anesthesiology. 2003;98:1415–1421
  6. Zimmer G. Acute pain management. In:  Tintinalli J,  Kelen G,  Stapczynski J editor. Emergency Medicine: A Comprehensive Study Guide. New York, NY: McGraw-Hill; 2004;p. 257–264
  7. Paris P, Yealy D. Pain management. In:  Marx JA editors. Rosen's Emergency Medicine: Concepts and Clinical Practice. St. Louis, MO: Mosby; 2002;p. 2555–2577
  8. Ungar JR, Brandes D, Reinoehl BM, et al. Pain management. In:  Schwartz GR editors. Principles and Practice of Emergency Medicine. 4th ed.. Baltimore, MD: Williams & Wilkens; 1999;
  9. Berkowitz BA, Ngai SH, Yang JC, et al. The disposition of morphine in surgical patients. Clin Pharmacol Ther. 1975;17:629–635
  10. Stanski DR, Greenblatt DJ, Lowenstein E. Kinetics of intravenous and intramuscular morphine. Clin Pharmacol Ther. 1978;24:52–59
  11. Bijur PE, Latimer CT, Gallagher EJ. Validation of a verbally administered numerical rating scale of acute pain for use in the emergency department. Acad Emerg Med. 2003;10:390–392
  12. Selbst SM, Clark M. Analgesic use in the emergency department. Ann Emerg Med. 1990;19:1010–1013
  13. Wilson JE, Pendleton JM. Oligoanalgesia in the emergency department. Am J Emerg Med. 1989;7:620–623
  14. Todd KH, Samaroo N, Hoffman JR. Ethnicity as a risk factor for inadequate emergency department analgesia. JAMA. 1993;269:1537–1539
  15. Karpman RR, Del Mar N, Bay C. Analgesia for emergency centers' orthopaedic patients: does an ethnic bias exist?. Clin Orthop. 1997;334:270–275

 Supervising editors: Knox H. Todd, MD, MPH; Michael L. Callaham, MDAuthor contributions: PEB, MKK, and EJG contributed to the concept, design, and writing. MKK was responsible for editing. PEB and EJG incorporated revisions. PEB conducted the analysis. PEB takes responsibility for the paper as a whole.Funding and support: This study was supported in part by a grant from the Agency for Healthcare Research and Quality 1 R01 HS13924.Reprints not available from the authors.

PII: S0196-0644(05)00334-3

doi: 10.1016/j.annemergmed.2005.03.010

Annals of Emergency Medicine
Volume 46, Issue 4 , Pages 362-367 , October 2005