Annals of Emergency Medicine
Volume 19, Issue 3 , Pages 319-321 , March 1990

The diagnostic utility of flumazenil (A benzodiazepine antagonist) in coma of unknown etiology

    MD, FACEP
  • Keith K Burkhart
    • , MD, FACEP
  • Kenneth W Kulig

      Affiliations

    • Corresponding Author InformationAddress for reprints: Kenneth W Kulig, MD, FACEP, Rocky Mountain Poison and Drug Center, 645 Bannock Street, Denver, Colorado 80204-4507.

Received 28 July 1989 ,Accepted 23 August 1989.

References 

  1. Klausen NO, Juhl O, Sorenson J, et al. Flumazenil in total intravenous anaesthesia using midazolam and fentanyl. Acta Anaesthesiol Scand. 1988;32:409–412
  2. Dunton AW, Schwam E, Pitman V, et al. The relationship between dose and duration of action of intravenous flumazenil in reversing sedation induced by a continuous infusion of medazolam. Eur J Anaesthesiol Suppl. 1988;2:97–102
  3. Lheureux P, Askenasu R. Double-blind study of Anexate in benzodiazepine intoxication. Eur J Anaesthesiol Suppl. 1988;2:300–304
  4. O'Sullivan GF, Wade DN. Flumazenil in the management of acute drug overdosage with benzodiazepines and other agents. Clin Pharmacol Ther. 1987;42:254–259
  5. Prischl F, Donner A, Grimm G, et al. Value of flumazenil in benzodiazepine self-poisoning. Med Toxicol. 1988;3:334–339
  6. Haefely W. The preclinical pharmacology of flumazenil. Eur J Anaesthesiol Suppl. 1988;2:25–36
  7. De Vry J, Slangen JL. The Ro 15-1788 cue: Evidence for benzodiazepine agonist and inverse agonist properties. Eur J Pharmacol. 1985;119:193–197
  8. Brogden RN, Goa KL. Flumazenil: A preliminary review of its benzodiazepine antagonist properties, intrinsic activity and therapeutic use. Drug. 1988;35:448–467
  9. Amrein R, Leishman B, Bentzinger C, et al. Flumazenil in benzodiazepine antagonism: Actions and clinical use in intoxications and anaesthesiology. Med Toxicol. 1987;2:411–429
  10. Nutt D, Costello M. Flumazenil and benzodiazepine withdrawal. Lancet. 1987;2:463

 Dr Burkhart's fellowship at the Rocky Mountain Poison and Drug Center was supported by a grant from Smith, Kline and French Laboratories.

PII: S0196-0644(05)82054-2

Annals of Emergency Medicine
Volume 19, Issue 3 , Pages 319-321 , March 1990

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