Annals of Emergency Medicine
Volume 47, Issue 3 , Pages 286-288 , March 2006

Is Flumazenil an Effective Treatment for Hepatic Encephalopathy?

  • Barbara G. Lock, MD

      Affiliations

    • Department of Emergency Medicine, Sound Shore Medical Center, New Rochelle, NY
  • ,
  • Kiran Pandit, MD, MPH

      Affiliations

    • New York Presbyterian Hospital Emergency Medicine Residency Program, New York Presbyterian Hospital, New York, NY
  • ,
  • EBEM Commentator Contact

      Affiliations

    • Corresponding Author InformationBarbara G. Lock, MD, Emergency Department, Sound Shore Medical Center, New Rochelle, NY

,Revised 1 January 2005 ,Accepted 1 January 2005.

References 

  1. Barbaro G , Di Lorenzo G , Soldini M , et al.   Flumazenil for hepatic encephalopathy grade II and IVa in patients with cirrhosis (an Italian multicenter double-blind placebo-controlled, cross-over study) . Hepatology . 1998;28:374–378
  2. Dursun M , Caliskan M , Canoruc F , et al.   The efficacy of flumazenil in subclinical to mild hepatic encephalopathic ambulatory patients (a prospective, randomised, double-blind, placebo-controlled study) . Swiss Med Weekly . 2003;133:118–123
  3. Goulenok C , Bernard B , Cadranel JF , et al.   Flumazenil vs. placebo in hepatic encephalopathy in patients with cirrhosis (a meta-analysis) . Aliment Pharmacol Ther . 2002;16:361–372
  4. Gyr K , Haussler J , Bouletreau P , et al.   Evaluation of the efficacy and safety of flumazenil in the treatment of portal systemic encephalopathy (a double blind, randomised placebo controlled multicentre study) . Gut . 1996;39:319–324
  5. Pomier-Layrargues G , Giguere JF , Lavoie J , et al.   Flumazenil in cirrhotic patients in hepatic coma (a randomized double-blind placebo-controlled crossover trial) . Hepatology . 1994;19:32–37
  6. Gitlin N , Lewis DC , Hinkley L . The diagnosis and prevalence of subclinical hepatic encephalopathy in apparently healthy ambulant, non-shunted patients with cirrhosis . J Hepatol . 1986;3:75–82
  7. Dallal GE. The little handbook of statistical practice. Available at: http://www.StatisticalPractice.com. Accessed December 26, 2005.
  8. Max MB , Lynn J . Interactive Textbook of Symptom Research . Bethesda, MD: National Institute of Dental and Craniofacial Research; 2000;

 Email barbaralock@hotmail.corn

PII: S0196-0644(06)00086-2

doi: 10.1016/j.annemergmed.2006.01.021

Annals of Emergency Medicine
Volume 47, Issue 3 , Pages 286-288 , March 2006