Annals of Emergency Medicine
Volume 48, Issue 5 , Pages 605-612 , November 2006

A Randomized, Controlled Trial of IV Versus IM Ketamine for Sedation of Pediatric Patients Receiving Emergency Department Orthopedic Procedures

Presented at the Pediatric Academic Societies’ meeting, May 2005, Washington, DC.

  • Mark G. Roback, MD

      Affiliations

    • Department of Pediatrics, Section of Emergency Medicine, University of Colorado School of Medicine, The Children’s Hospital, Denver, CO
    • Corresponding Author InformationAddress for correspondence: Mark G. Roback, MD, Emergency Department, The Children’s Hospital, 1056 E. 19th Avenue, B251, Denver, CO 80218; 303-837-2888, fax 303-764-8694
    • ,
  • Joe E. Wathen, MD

      Affiliations

    • Department of Pediatrics, Section of Emergency Medicine, University of Colorado School of Medicine, The Children’s Hospital, Denver, CO
    • ,
  • Todd MacKenzie, PhD

      Affiliations

    • Department of Medicine, Dartmouth Medical School, Hanover, NH
    • ,
  • Lalit Bajaj, MD, MPH

      Affiliations

    • Department of Pediatrics, Section of Emergency Medicine, University of Colorado School of Medicine, The Children’s Hospital, Denver, CO

Received 9 November 2005 ,Revised 4 May 2006 ,Accepted 11 May 2006.

References 

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  2. Parker RI, Mahan RA, Giugliano D, et al. Efficacy and safety of intravenous midazolam and ketamine as sedation for therapeutic and diagnostic procedures in children. Pediatrics. 1997;99:427–431
  3. Green SM, Rothrock SG, Harris T, et al. Intravenous ketamine for pediatric sedation in the emergency department: safety profile with 156 cases. Acad Emerg Med. 1998;10:971–976
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  7. Petrack EM, Marx CM, Wright MS. Intramuscular ketamine is superior to meperidine, promethazine, and chlorpromazine for pediatric emergency department sedation. Arch Pediatr Adolesc Med. 1996;150:665–667
  8. Green SM, Kuppermann N, Rothrock SG, et al. Predictors of adverse events with intramuscular ketamine sedation in children. Ann Emerg Med. 2000;35:35–42
  9. Kennedy RM, Porter FL, Miller JP, et al. Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic procedures. Pediatrics. 1998;102:956–963
  10. Sherwin TS, Green SM, Khan A, et al. Does adjunctive midazolam reduce recovery agitation after ketamine sedation for pediatric procedures? (a randomized, double-blind, placebo-controlled trial). Ann Emerg Med. 2000;35:3:229–238
  11. Wathen J, Roback MG, MacKenzie T, et al. Does midazolam alter the clinical effects of intravenous ketamine sedation in children? (a double-blind, randomized, controlled emergency department trial). Ann Emerg Med. 2000;36:579–588
  12. Roback MG, Wathen JE, Bajaj L, et al. Adverse events associated with procedural sedation and analgesia in a pediatric emergency department: a comparison of common parenteral drugs. Acad Emerg Med. 2005;12:508–513
  13. Pitetti RD, Singh S, Clyde Pierce M. Safe and efficacious use of procedural sedation and analgesia by nonanesthesiologists in a pediatric emergency department. Arch Pediatr Adolesc Med. 2003;157:1090–1096
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  18. American Society of Anesthesiologists. Practice guidelines for sedation and analgesia by non-anesthesiologists. Anesthesiology. 2002;96:1004–1017
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  22. Practice guidelines for sedation and analgesia by non-anesthesiologists. Anesthesiology. 2002;96:1004–1017
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 Supervising editor: Steven M. Green, MDAuthor contributions: MGR, JEW, and TM conceived the study. MGR and JEW oversaw data collection. MGR, JEW, and LB managed the data, including quality control. TM provided statistical advice on study design. TM and LB analyzed the data. MGR drafted the manuscript, and all authors contributed substantially to its revision. MGR takes responsibility for the paper as a whole.Reprints not available from the authors.Funding and support: Grant support was from The Children’s Hospital Research Institute.

PII: S0196-0644(06)00783-9

doi: 10.1016/j.annemergmed.2006.06.001

Annals of Emergency Medicine
Volume 48, Issue 5 , Pages 605-612 , November 2006

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