Annals of Emergency Medicine
Volume 49, Issue 4 , Pages 468-480.e2, April 2007

Tramadol/Acetaminophen or Hydrocodone/Acetaminophen for the Treatment of Ankle Sprain: A Randomized, Placebo-Controlled Trial

  • David J. Hewitt, MD

      Affiliations

    • PriCara, Unit of Ortho-McNeil, Inc., Raritan, NJ
    • Corresponding Author InformationAddress for correspondence: David J. Hewitt, MD, PriCara, Unit of Ortho-McNeil, Inc., 1000 Route 202, Raritan, NJ 08869-0602; 908-218-6419, fax 908-518-7051.
  • ,
  • Knox H. Todd, MD, MPH

      Affiliations

    • Pain and Emergency Medicine Institute, Beth Israel Medical Center, New York, NY
  • ,
  • Jim Xiang, PhD

      Affiliations

    • Ortho-McNeil Janssen Scientific Affairs, LLC, Raritan, NJ.
  • ,
  • Donna M. Jordan, BSN

      Affiliations

    • PriCara, Unit of Ortho-McNeil, Inc., Raritan, NJ
  • ,
  • Norman R. Rosenthal, MD

      Affiliations

    • PriCara, Unit of Ortho-McNeil, Inc., Raritan, NJ
  • ,
  • CAPSS-216 Study Investigators

Received 9 December 2005; received in revised form 15 May 2006, 24 July 2006 and 4 August 2006; accepted 9 August 2006. published online 23 November 2006.

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 Supervising editor: Steven M. Green, MDAuthor contributions: DJH, KHT, DMJ, and NRR conceived the study, designed the trial, and obtained research funding. DJH and DMJ oversaw recruitment of participating centers. JX provided statistical advice on study design and analyzed the data. DJH drafted the article, and all named authors contributed substantially to its revision. The CAPSS-216 Study Investigators supervised the conduct of the trial, recruitment of subjects, and data collection. DJH takes responsibility for the paper as a whole.Funding and support: This study was supported by a grant from PriCara, Unit of Ortho McNeil, Inc.Available online November 20, 2006.Reprints not available from the authors.

PII: S0196-0644(06)02150-0

doi:10.1016/j.annemergmed.2006.08.030

Annals of Emergency Medicine
Volume 49, Issue 4 , Pages 468-480.e2, April 2007