Annals of Emergency Medicine
Volume 49, Issue 6 , Pages 802-805 , June 2007

Potential Interference by Hydroxocobalamin on Cooximetry Hemoglobin Measurements During Cyanide and Smoke Inhalation Treatments

  • Jangwoen Lee, PhD

      Affiliations

    • Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA
    • ,
  • David Mukai, BS

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Irvine, CA.
    • ,
  • Kelly Kreuter, MA

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Irvine, CA.
    • ,
  • Sari Mahon, PhD

      Affiliations

    • Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA
    • ,
  • Bruce Tromberg, PhD

      Affiliations

    • Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA
    • ,
  • Matthew Brenner, MD

      Affiliations

    • Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA
    • Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Irvine, CA.
    • Corresponding Author InformationAddress for correspondence: Matthew Brenner, MD, 101 The City Drive South, Bldg 53, Rm 119, Rt 81, University of California Irvine, Orange, CA 92037-0976; 714-456-5150, fax 858-657-7075

Received 5 June 2006 ,Revised 10 November 2006 ,Accepted 15 November 2006.

References 

  1. Linnell JC. The role of cobalamins in cyanide detoxication. In:  Ballantyne B,  Marrs TC editor. Clinical and Experimental Toxicology of Cyanides. Bristol, England: IOP Publishing Limited; 1987;
  2. Fortin J-C, Giocanti J-P, Ruttimann M, et al. Prehospital administration of hydroxocobalamin for smoke inhalation-associated cyanide poisoning: 8 years of experience in the Paris fire brigade. Clin Toxicol. 2006;44(suppl 1):37–44
  3. Samuel WS, Keim ME. Hydroxocobalamin: improved public health readiness for cyanide disasters. Ann Emerg Med. 2001;37:635–641
  4. Geller RJ, Barthold C, Saiers JA, et al. Pediatric cyanide poisoning: causes, manifestations, and unmet needs. Pediatrics. 2006;118:2146–2158
  5. Baud FJ, Barriot P, Toffis V, et al. Elevated blood cyanide concentrations in victims of smoke inhalation. N Engl J Med. 1991;325:1761–1766
  6. Curry SC, Connor DA, Raschke RA. Effect of the cyanide antidote hydroxocobalamin on commonly ordered serum chemistry studies. Ann Emerg Med. 1994;24:65–67
  7. Zijlstra WG, Buursma A, Assendelft OW. Visible and Near-Infrared Absorption Spectra of Human and Animal Hemoglobin. AH Zeist, Netherlands: VSP BV; 2000;
  8. Metzler CM. Usefulness of the two-compartment open model in pharmacokinetics. J Am Stat Assoc. 1971;66:49–53
  9. de La Coussaye JE, Houeto P, Sandouk P, et al. Pharmacokinetics of hydroxocobalamin in dogs. J Neurosurg Anesthesiol. 1994;6:111–115
  10. Forsyth JC, Mueller PD, Becker CE, et al. Hydroxocobalamin as a cyanide antidote: safety, efficacy and pharmacokinetics in heavily smoking normal volunteers. J Toxicol Clin Toxicol. 1993;31:277–294

 Supervising editor: Stephen R. Thom, MD, PhDAuthor contributions: JL, BT, and MB conceived the study and obtained the research funding. JL, DM, SM, and MB designed and supervised the conduct of the experiments and obtained study approvals. JL, DM, and KK conducted the experiments and managed data. JL drafted the article. SM and MB contributed substantially to its revision and finalization. MB takes responsibility for the paper as a whole.Funding and support: This work is based on research sponsored by the Air Force Research Laboratory, under agreement number FA9550-04-1-0101. The US government is authorized to reproduce and distribute reprints for governmental purposes, notwithstanding any copyright notation thereon. This work is also supported by Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, grant No. 445574-30133.Publication dates: Available online January 8, 2007.Reprints not available from the authors.

PII: S0196-0644(06)02540-6

doi: 10.1016/j.annemergmed.2006.11.016

Annals of Emergency Medicine
Volume 49, Issue 6 , Pages 802-805 , June 2007

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