Annals of Emergency Medicine
Volume 50, Issue 2 , Pages 153-158.e1 , August 2007

ST2 in Emergency Department Chest Pain Patients With Potential Acute Coronary Syndromes

  • Aaron M. Brown, BS

      Affiliations

    • Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
    • ,
  • Alan H.B. Wu, PhD

      Affiliations

    • Department of Laboratory Medicine, University of California, San Francisco, Clinical Chemistry Laboratory, San Francisco General Hospital, San Francisco, CA
    • ,
  • Paul Clopton, MSc

      Affiliations

    • Statistical Research Department, University of California, and the Veterans Affairs Healthcare System, Department of Statistics, San Diego, CA.
    • ,
  • Jennifer L. Robey, MSN

      Affiliations

    • Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
    • ,
  • Judd E. Hollander, MD

      Affiliations

    • Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
    • Corresponding Author InformationAddress for correspondence: Judd E. Hollander, MD, Hospital of the University of Pennsylvania, Department of Emergency Medicine, Ground Floor, Ravdin Building, 3400 Spruce St, Philadelphia, PA 19104; fax 215-662-3953.

Received 3 September 2006 ,Revised 29 January 2007 ,Accepted 9 February 2007.

References 

  1. McCaig LF, Burt CW. National Hospital Ambulatory Medical Care Survey: 2002 emergency department summary. Adv Data. 2004;340:1–34
  2. Weinberg EO, Shimpo M, De Keulenaer GW, et al. Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. Circulation. 2002;106:2961–2966
  3. Shimpo M, Morrow DA, Weinberg EO, et al. Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction. Circulation. 2004;109:2186–2190
  4. Marsan RJ, Shaver KJ, Sease KL, et al. Evaluation of a clinical decision rule for young adult patients with chest pain. Acad Emerg Med. 2005;12:26–31
  5. Hollander JE, Blomkalns AL, Brogan GX, et al. Multidisciplinary Standardized Reporting Criteria Task Force Standardized Reporting Criteria Working Group of Emergency Medicine Cardiac Research and Education Group-International Standardized reporting guidelines for studies evaluating risk stratification of emergency department patients with potential acute coronary syndromes. Ann Emerg Med. 2004;44:589–598
  6. Alpert JS, Thygesen K, Antman E, et al. Myocardial infarction redefined—a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36:959–969
  7. Tajima S, Oshikawa K, Tominaga S, et al. The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis. Chest. 2003;124:1206–1214
  8. Oshikawa K, Kuroiwa K, Tago K, et al. Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation. Am J Respir Crit Care Med. 2001;164:277–281
  9. Weinberg EO, Shimpo M, Hurwitz S, et al. Identification of serum soluble ST2 receptor as a novel heart failure biomarker. Circulation. 2003;107:721–726
  10. Brunner M, Krenn C, Roth G, et al. Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma. Intensive Care Med. 2004;30:1468–1473
  11. Lohning M, Stroehmann A, Coyle AJ, et al. T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci U S A. 1998;95:6930–6905

 Supervising editors: W. Brian Gibler, MD; Michael L. Callaham, MDAuthor contributions: AMB, JLR, and JEH were responsible for study concept and design. JEH obtained funding. AMB, AHBW, JLR, and JEH were responsible for data collection. AMB, and PC conducted data analysis. AMB, AHBW, PC, JLR, and JEH were responsible for interpretation of results. AMB and JEH drafted the article. AMB, AHBW, PC, JLR, and JEH were responsible for critical revision of manuscript. JEH takes responsibility for the paper as a whole.Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article, that might create any potential conflict of interest. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. Funding for this research was in part provided by an unrestricted grant from Critical Care Diagnostics Inc, New York, NY.Reprints not available from the authors.Available online April 27, 2007.

PII: S0196-0644(07)00213-2

doi: 10.1016/j.annemergmed.2007.02.015

Annals of Emergency Medicine
Volume 50, Issue 2 , Pages 153-158.e1 , August 2007

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