Annals of Emergency Medicine
Volume 50, Issue 3 , Pages 292-313 , September 2007

Clinical Policy: Critical Issues in the Management of Patients Presenting to the Emergency Department With Acetaminophen Overdose

References 

  1. Scalley RD, Conner CS. Acetaminophen poisoning: a case report of the use of acetylcysteine. Am J Hosp Pharm. 1976;35:964–967
  2. Smilkstein MJ, Bronstein AC, Linden C, et al. Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med. 1991;20:1058–1063
  3. Perry HE, Shannon MW. Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: results of an open-label clinical trial. J Pediatr. 1998;132:149–152
  4. Buckley NA, Buckley N, Whyte IM, et al. Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning?. J Toxicol Clin Toxicol. 1999;37:759–767
  5. Woo OF, Mueller PD, Olson KR, et al. Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose. Ann Emerg Med. 2000;35:363–368
  6. Amirzadeh A, McCotter C. The intravenous use of oral acetylcysteine (mucomyst) for the treatment of acetaminophen overdose. Arch Intern Med. 2002;162:96–97
  7. Yip L, Dart RC. A 20-hour treatment for acute acetaminophen overdose. N Engl J Med. 2003;348:2471–2472
  8. Kanter MZ. Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning. Am J Health Syst Pharm. 2006;63:1821–1827
  9. Clark RF, Chen R, Williams SR, et al. The use of ondansetron in the treatment of nausea and vomiting associated with acetaminophen poisoning. J Toxicol Clin Toxicol. 1996;34:163–167
  10. Scharman EJ. Use of ondansetron and other antiemetics in the management of toxic acetaminophen ingestions. J Toxicol Clin Toxicol. 1998;36:19–25
  11. Wright RO, Anderson AC, Lesko SL, et al. Effect of metoclopramide dose on preventing emesis after oral administration of N-acetylcysteine for acetaminophen overdose. J Toxicol Clin Toxicol. 1999;37:35–42
  12. Spiller HA, Krenzelok EP, Grande GA, et al. A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose. Ann Emerg Med. 1994;23:519–523
  13. Bailey B, McGuigan MA. Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med. 1998;31:710–715
  14. Kerr F, Dawson A, Whyte IM, et al. The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Ann Emerg Med. 2005;45:402–408
  15. Appelboam AV, Dargan PI, Knighton J. Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma. Emerg Med J. 2002;19:594–595
  16. Rumack BH, Matthew H. Acetaminophen poisoning and toxicity. Pediatrics. 1975;55:871–876
  17. Rumack BH, Peterson RC, Koch GG, et al. Acetaminophen overdose: 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med. 1981;141:380–385
  18. Daly FFS, O’Malley GF, Heard K, et al. Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion. Ann Emerg Med. 2004;44:393–398
  19. Dart RC, Erdman AR, Olson KR, et al. Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Tox. 2006;44:1–18
  20. Schiodt FV, Rochling FA, Casey DL, et al. Acetaminophen toxicity in an urban county hospital. N Engl J Med. 1997;337:1112–1117
  21. Bond GR, Hite LK. Population-based incidence and outcome of acetaminophen poisoning by type of ingestion. Acad Emerg Med. 1999;6:1115–1120
  22. American College of Emergency Physicians. Clinical policy for the initial approach to patients presenting with acute toxic ingestion or dermal or inhalation exposure. Ann Emerg Med. 1999;33:735–761
  23. Schriger DL, Cantrill SV, Greene CS. The origins, benefits, harms, and implications of emergency medicine clinical policies. Ann Emerg Med. 1993;22:597–602
  24. Prescott LF, Illingworth RN, Critchley JA, et al. Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning. BMJ. 1979;2:1097–1100
  25. Smilkstein MJ, Knapp GL, Kulig KW, et al. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose (Analysis of the national multicenter study (1976 to 1985)). N Engl J Med. 1988;319:1557–1562
  26. Parker D, White JP, Paton D, et al. Safety of late acetylcysteine treatment in paracetamol poisoning. Hum Exp Toxicol. 1990;9:25–27
  27. Peterson RG, Rumack BH. Treating acute acetaminophen poisoning with acetylcysteine. JAMA. 1977;237:2406–2407
  28. Prescott LF, Ballantyne A, Proudfoot AT, et al. Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet. 1977;310:432–434
  29. Oh TE, Shenfield GM. Intravenous N-acetylcysteine for paracetamol poisoning. Med J Aust. 1980;1:664–665
  30. Keays R, Harrison PM, Wendon JA, et al. Intravenous acetylcysteine in paracetamol-induced fulminant hepatic failure: a prospective controlled trial. BMJ. 1991;303:1026–1029
  31. Harrison PM, Keays R, Bray GP, et al. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine. Lancet. 1990;335:1572–1573
  32. Cetaruk EW, Dart RC, Hurlbut KM, et al. Tylenol Extended Relief overdose. Ann Emerg Med. 1997;30:104–108
  33. Bizovi KE, Aks SE, Paloucek F, et al. Late increase in acetaminophen concentration after overdose of Tylenol Extended Relief. Ann Emerg Med. 1996;28:549–551
  34. Seeff LB, Cuccherini BA, Zimmerman HJ, et al. Acetaminophen hepatotoxicity in alcoholics (A therapeutic misadventure). Ann Intern Med. 1986;104:399–404
  35. Ambre J, Alexander M. Liver toxicity after acetaminophen ingestion (Inadequacy of the dose estimate as an index of risk). JAMA. 1977;238:500–501
  36. Davis AM, Helms CM, Mitros FA, et al. Severe hepatic damage after acetaminophen use in psittacosis. Am J Med. 1983;74:349–352
  37. Lane JE, Belson MG, Brown DK, et al. Chronic acetaminophen toxicity: a case report and review of the literature. J Emerg Med. 2002;23:253–256
  38. Kaysen GA, Pond SM, Roper MH, et al. Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen. Arch Intern Med. 1985;145:2019–2023
  39. Wootton FT, Lee WM. Acetaminophen hepatotoxicity in the alcoholic. South Med J. 1990;83:1047–1049
  40. McClain CJ, Holtzman J, Allen J, et al. Clinical features of acetaminophen toxicity. J Clin Gastroenterol. 1988;10:76–80
  41. Black M, Cornell JF, Rabin L, et al. Late presentation of acetaminophen hepatotoxicity. Dig Dis Sci. 1982;27:370–374
  42. Bravo-Fernandez EF, Reddy KR, Jeffers L, et al. Hepatotoxicity after prolonged use of acetaminophen: a case report. Bol Asoc Med P R. 1988;80:417–419
  43. Goldfinger R, Ahmed KS, Pitchumoni CS, et al. Concomitant alcohol and drug abuse enhancing acetaminophen toxicity (Report of a case). Am J Gastroenterol. 1978;70:385–388
  44. O’Dell JR, Zetterman RK, Burnett DA. Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic. JAMA. 1986;255:2636–2637
  45. Johnson MW, Friedman PA, Mitch WE. Alcoholism, nonprescription drug and hepatotoxicity (The risk from unknown acetaminophen ingestion). Am J Gastroenterol. 1981;76:530–533
  46. Barker JD, de Carle DJ, Anuras S. Chronic excessive acetaminophen use and liver damage. Ann Intern Med. 1977;87:299–301
  47. Gerber MA, Kaufmann H, Klion F, et al. Acetaminophen associated hepatic injury, report of two cases showing unusual portal tract reactions. Hum Pathol. 1980;11:37–42
  48. Leist MH, Gluskin LE, Payne JA. Enhanced toxicity of acetaminophen in alcoholics: report of three cases. J Clin Gastroenterol. 1985;7:55–59
  49. Watkins PB, Kaplowitz N, Slattery JT, et al. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA. 2006;296:87–93
  50. Floren CH, Thesleff P, Nilsson A. Severe liver damage caused by therapeutic doses of acetaminophen. Acta Med Scand. 1987;222:285–288
  51. Bolesta S, Haber SL. Hepatotoxicity associated with chronic acetaminophen administration in patients without risk factors. Ann Pharmacother. 2002;36:331–333
  52. Kumar S, Rex DK. Failure of physicians to recognize acetaminophen hepatotoxicity in chronic alcoholics. Arch Intern Med. 1991;151:1189–1191
  53. Kuffner EK, Dart RC, Bogdan GM, et al. Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial. Arch Intern Med. 2001;161:2247–2252
  54. Benson GD. Acetaminophen in chronic liver disease. Clin Pharmacol Ther. 1983;33:95–101
  55. Dart RC, Kuffner EK, Rumack BH. Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. Am J Ther. 2000;7:123–134

PII: S0196-0644(07)00731-7

doi: 10.1016/j.annemergmed.2007.06.014

Annals of Emergency Medicine
Volume 50, Issue 3 , Pages 292-313 , September 2007