Annals of Emergency Medicine
Volume 52, Issue 1 , Pages 22-29.e6 , July 2008

The Role of Oral Ondansetron in Children With Vomiting as a Result of Acute Gastritis/Gastroenteritis Who Have Failed Oral Rehydration Therapy: A Randomized Controlled Trial

Presented at the Society for Academic Emergency Medicine Midwest regional meeting, September 2005, Detroit, MI; and at the Society for Academic Emergency Medicine annual meeting, May 2006, San Francisco, CA.

  • Gregory Roslund, MD

      Affiliations

    • Department of Emergency Medicine, St. Joseph Regional Medical Center, South Bend, IN
    • Corresponding Author InformationAddress for correspondence: Gregory Roslund, MD, St. Joseph Regional Medical Center, 801 E LaSalle Ave, South Bend, IN 46617; 574-239-6146, fax 574-472-6033
    • ,
  • Terri S. Hepps, MD

      Affiliations

    • Department of Emergency Medicine, Northwest Community Hospital, Arlington Heights, IL
    • ,
  • Kemedy K. McQuillen, MD

      Affiliations

    • Department of Emergency Medicine, Central Maine Medical Center, Lewiston, ME.

Received 26 July 2006 ,Revised 6 August 2007 ,Accepted 13 September 2007.

References 

  1. American Academy of Pediatrics. Practice parameter: the management of acute gastroenteritis in young children (American Academy of Pediatrics. Provisional Committee on Quality Improvement, Subcommittee on Acute Gastroenteritis). Pediatrics. 1996;97:424–435
  2. Ernst AA, Weiss SJ, Park S. Prochlorperazine versus promethazine for uncomplicated nausea and vomiting in the emergency department: a randomized, double-blind clinical trial. Ann Emerg Med. 2000;36:89–94
  3. DeGrandi T. Promethazine-induced dystonic reaction. Pediatr Emerg Care. 1987;3:91–92
  4. Milburn W. Toxic effects of metoclopramide. Pediatr Rev. 1992;13:117
  5. Phenergan (promethazine HCl). Madison, NJ: Wyeth Pharmaceuticals, Inc; 2004;[package insert]
  6. Cubeddu LX, Trujillo LM, Talmaciu I, et al. Antiemetic activity of ondansetron in acute gastroenteritis. Aliment Pharmacol Ther. 1997;11:185–191
  7. Reeves JJ, Shannon MW, Fleisher GR. Ondansetron decreases vomiting associated with acute gastroenteritis: a randomized, controlled trial. Pediatrics. 2002;109:e62
  8. Ramsook C, Sahagun-Carreon I, Kozinetz CA, et al. A randomized clinical trial comparing oral ondansetron with placebo in children with vomiting from acute gastroenteritis. Ann Emerg Med. 2002;39:397–403
  9. Freedman SB, Adler M, Seshadri R, et al. Oral ondansetron for gastroenteritis in a pediatric emergency department. N Engl J Med. 2006;354:1698–1705

 Reprints not available from the authors.

 Author contributions: TSH and KKM conceived the study and designed the trial. KKM supervised the conduct of the trial and data collection and managed the data. GR, TSH, and KKM enrolled subjects and guided other physicians in the department as they enrolled patients. KKM provided statistical advice on study design and analyzed the data. GR and KKM drafted the article, and TSH contributed substantially to its revision. GR takes responsibility for the paper as a whole.

 Supervising editor: David M. Jaffe, MD

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article, that might create any potential conflict of interest. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. GlaxoSmithKline supplied placebo tablets but no other financial or in-kind support for this study.

 The authors were previously affiliated with the Department of Emergency Medicine, Advocate Christ Medical Center, Oak Lawn, IL.

 Publication dates: Available online November 19, 2007.

PII: S0196-0644(07)01546-6

doi: 10.1016/j.annemergmed.2007.09.010

Annals of Emergency Medicine
Volume 52, Issue 1 , Pages 22-29.e6 , July 2008

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