Annals of Emergency Medicine
Volume 52, Issue 4 , Pages 399-406 , October 2008

A Randomized Controlled Trial of Prochlorperazine Versus Metoclopramide for Treatment of Acute Migraine

Presented at the American Headache Society annual meeting, June 2007, Chicago, IL.

  • Benjamin W. Friedman, MD, MS

      Affiliations

    • Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY
    • Corresponding Author InformationAddress for correspondence: Benjamin W. Friedman, MD, MS, Department of Emergency Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467; 718-920-6626, fax 718-798-0730
    • ,
  • David Esses, MD

      Affiliations

    • Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY
    • ,
  • Clemencia Solorzano, RPh

      Affiliations

    • Department of Pharmacy, Montefiore Medical Center, Bronx, NY
    • ,
  • Niels Dua, MD

      Affiliations

    • Division of Emergency Medicine, New York–Presbyterian Hospital/Columbia University Medical Center, New York, NY
    • ,
  • Peter Greenwald, MD

      Affiliations

    • Division of Emergency Medicine, New York–Presbyterian Hospital/Columbia University Medical Center, New York, NY
    • ,
  • Radu Radulescu, MD

      Affiliations

    • Division of Emergency Medicine, New York–Presbyterian Hospital/Columbia University Medical Center, New York, NY
    • ,
  • Esther Chang, PharmD

      Affiliations

    • Research Pharmacy, Columbia University Medical Center, New York, NY
    • ,
  • Michael Hochberg, MD

      Affiliations

    • Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY
    • ,
  • Caron Campbell, MD

      Affiliations

    • Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY
    • ,
  • Amish Aghera, MD

      Affiliations

    • Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY
    • ,
  • Tyson Valentin, BA

      Affiliations

    • Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY
    • ,
  • Joseph Paternoster, RN

      Affiliations

    • Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY
    • ,
  • Polly Bijur, PhD

      Affiliations

    • Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY
    • ,
  • Richard B. Lipton, MD

      Affiliations

    • Department of Neurology, Albert Einstein College of Medicine, Bronx, NY
    • ,
  • E. John Gallagher, MD

      Affiliations

    • Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY

Received 28 June 2007 ,Revised 28 August 2007 ,Accepted 21 September 2007.

References 

  1. Bigal ME, Bordini CA, Speciali JG. Intravenous chlorpromazine in the emergency department treatment of migraines: a randomized controlled trial. J Emerg Med. 2002;23:141–148
  2. Colman I, Brown MD, Innes GD, et al. Parenteral metoclopramide for acute migraine: meta-analysis of randomised controlled trials. BMJ. 2004;329:1369–1373
  3. Friedman BW, Hochberg M, Esses D, et al. A clinical trial of trimethobenzamide/diphenhydramine versus sumatriptan for acute migraines. Headache. 2006;46:934–941
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  9. Friedman BW, Corbo J, Lipton RB, et al. A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines. Neurology. 2005;64:463–468
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  18. Carleton SC, Shesser RF, Pietrzak MP, et al. Double-blind, multicenter trial to compare the efficacy of intramuscular dihydroergotamine plus hydroxyzine versus intramuscular meperidine plus hydroxyzine for the emergency department treatment of acute migraine headache. Ann Emerg Med. 1998;32:129–138
  19. Ducharme J, Beveridge RC, Lee JS, et al. Emergency management of migraine: is the headache really over?. Acad Emerg Med. 1998;5:899–905
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 Supervising editor: Knox H. Todd, MD, MPH

 Author contributions: BWF, DE, CS, EC, MH, JP, PB, and EJG conceived the study and designed the trial. BWF, RBL, and EJG obtained research funding. BWF, ND, PG, RR, and TV supervised the conduct of the trial and data collection. BWF, TV, ND, PG, and RR undertook recruitment of participating centers and patients. BWF, CC, and AA managed the data, including quality control. BWF, PB, RBL, and EJG provided statistical advice on study design and analyzed the data. BWF drafted the article, and all authors contributed substantially to its revision. BWF takes responsibility for the paper as a whole.

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article, that might create any potential conflict of interest. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. Dr. Friedman is supported through a career development award (1K23NS051409-01A1) from the National Institute of Neurological Disorders and Stroke.

 Publication dates: Available online November 19, 2007.

 Reprints not available from the authors.

PII: S0196-0644(07)01557-0

doi: 10.1016/j.annemergmed.2007.09.027

Annals of Emergency Medicine
Volume 52, Issue 4 , Pages 399-406 , October 2008

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