Annals of Emergency Medicine
Volume 51, Issue 4 , Pages 449-450 , April 2008

Lipid Emulsion Therapy in Lipophilic Drug Toxicity

  • Grant Cave, BHB, MBChB

      Affiliations

    • Emergency Medical Systems Australia, Melbourne, Victoria, Australia
    • ,
  • Martyn Harvey, BHB, MBChB

      Affiliations

    • Department of Emergency Medicine, Waikato Hospital, Hamilton, New Zealand

References 

  1. Henretig , et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med. 2008;51:412–415
  2. Weinberg G, Ripper R, Feinstein D, et al. Lipid emulsion infusion rescues dogs from bupivacaine induced cardiac toxicity. Reg Anesth Pain Med. 2003;28:198–202
  3. Rosenblatt M, Abel M, Fischer G, et al. Successful use of a 20% lipid emulsion to resuscitate a patient after presumed bupivacaine related cardiac arrest. Anaesthesia. 2006;105:217–218
  4. Harvey M, Cave G. Intralipid outperfroms sodium bicarbonate in a rabbit model of clomipramine toxicity. Ann Emerg Med. 2007;49:178–185
  5. Tebbutt S, Harvey M, Nicholson T, et al. Intralipid prolongs survival in a rat model of verapamil toxicity. Acad Emerg Med. 2006;13:134–139
  6. The Association of Anaesthetists of Great Britain and Ireland. Guidelines for the management of severe local anaesthetic toxicity. The Association of Anaesthetists of Great Britain and Ireland Website http://www.aagbi.org/publications/guidelines/docs/latoxicity07.pdfAccessed October 2, 2007

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article, that might create any potential conflict of interest. The authors have stated that no such relationships exist. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement.

PII: S0196-0644(07)01673-3

doi: 10.1016/j.annemergmed.2007.10.014

Annals of Emergency Medicine
Volume 51, Issue 4 , Pages 449-450 , April 2008

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