Annals of Emergency Medicine
Volume 52, Issue 1 , Pages 69-75.e1 , July 2008

Is Fluid Therapy Associated With Cerebral Edema in Children With Diabetic Ketoacidosis?

  • Jeffrey Hom, MD, MPH

      Affiliations

    • Corresponding Author InformationAddress for correspondence: Jeffrey Hom, MD, MPH, Department of Emergency Medicine, Box 1228, SUNY–Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203; 718-245-4790, fax 718-245-4799
    • ,
  • Richard Sinert, DO

References 

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  2. Dunger DB, Sperling MA, Acerini CL, et al. European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents. Pediatrics. 2004;113:e133–e140
  3. Harris GD, Fiordalisi I, Harris WL, et al. Minimizing the risk of brain herniation during treatment of diabetic ketoacidemia: a retrospective and prospective study. J Pediatr. 1990;117(1 pt 1):22–31
  4. Harris GD, Fiordalisi I. Physiologic management of diabetic ketoacidemia (A 5-year prospective pediatric experience in 231 episodes). Arch Pediatr Adolesc Med. 1994;148:1046–1052
  5. Marcin JP, Glaser N, Barnett P, et al. Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema. J Pediatr. 2002;141:793–797
  6. Felner EI, White PC. Improving management of diabetic ketoacidosis in children. Pediatrics. 2001;108:735–740
  7. Hale PM, Rezvani I, Braunstein AW, et al. Factors predicting cerebral edema in young children with diabetic ketoacidosis and new onset type I diabetes. Acta Pediatr. 1997;86:626–631
  8. Mel JM, Werther GA. Incidence and outcome of diabetic cerebral oedema in childhood: are there predictors?. J Paediatr Child Health. 1995;31:17–20
  9. Edge JA, Jakes RW, Roy Y, et al. The UK case-control study of cerebral oedema complicating diabetic ketoacidosis in children. Diabetologia. 2006;49:2002–2009
  10. Glaser N, Barnett P, McClaslin I, et al. Risk factors for cerebral edema in children with diabetic ketoacidosis (The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics). N Engl J Med. 2001;344:264–269
  11. Lawrence SE, Cummings EA, Gaboury I, et al. Population-based study of incidence and risk factors for cerebral edema in pediatric diabetic ketoacidosis. J Pediatr. 2005;146:688–692
  12. Levine M, Haslam D, Walter S, et al. Harm. In:  Guyatt G,  Rennie D editor. Users' Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice. Chicago, IL: AMA Press; 2002;p. 81–100

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article that might create any potential conflict of interest. The authors have stated that no such relationships exist. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement.

 Reprints not available from the authors.

PII: S0196-0644(08)00368-5

doi: 10.1016/j.annemergmed.2008.01.330

Annals of Emergency Medicine
Volume 52, Issue 1 , Pages 69-75.e1 , July 2008

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