Annals of Emergency Medicine
Volume 54, Issue 3 , Pages 409-420 , September 2009

A Bacterial Cocaine Esterase Protects Against Cocaine-Induced Epileptogenic Activity and Lethality

Received 16 January 2008 ,Revised 12 September 2008 ,Accepted 23 September 2008.

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 Supervising editor: Stephen R. Thom, MD, PhD

 Author contributions: EMJ and JHW conceived the study and designed the experiments. EMJ, MGB, and ZDC performed the data collection and analysis. DN and RKS produced and purified the cocaine esterase used in this study. EMJ drafted the article, and all authors contributed to the revisions. EMJ and JHW take responsibility for the paper as a whole.

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article, that might create any potential conflict of interest. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. This work was supported by grants from the United States Public Health Service DA021416 and T32 DA07268.

 Reprints not available from the authors.

 Publication date: Available online November 14, 2008.

PII: S0196-0644(08)01787-3

doi: 10.1016/j.annemergmed.2008.09.023

Annals of Emergency Medicine
Volume 54, Issue 3 , Pages 409-420 , September 2009

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