Annals of Emergency Medicine
Volume 53, Issue 4 , Pages 536-543 , April 2009

Empiric Antibiotic Therapy for Sepsis Patients: Monotherapy With β-Lactam or β-Lactam Plus an Aminoglycoside? Answers to the November 2008 Journal Club Questions

  • Teri A. Reynolds, MD, PhD

      Affiliations

    • Alameda County Medical Center-Highland Campus, Oakland, CA
    • ,
  • Tyler W. Barrett, MD (Section Editor)

      Affiliations

    • Vanderbilt University Medical Center, Nashville, TN
    • ,
  • David L. Schriger, MD, MPH (Section Editor)

      Affiliations

    • University of California, Los Angeles, CA

References 

  1. Paul M, Silbiger I, Grozinsky S, et al. Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis. Cochrane Database Syst Rev. 2006;(1):CD003344
  2. Leibovici L, Paul M, Poznanski O, et al. Monotherapy versus beta-lactam-aminoglycoside combination treatment for gram-negative bacteremia: a prospective, observational study. Antimicrob Agents Chemother. 1997;41:1127–1133
  3. Hilf M, Yu VL, Sharp J, et al. Antibiotic therapy for Pseudomonas aeruginosa bacteremia: outcome correlations in a prospective study of 200 patients. Am J Med. 1989;87:540–546
  4. Safdar N, Handelsman J, Maki DG. Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? (a meta-analysis). Lancet Infect Dis. 2004;4:519–527
  5. Paul M, Soares-Weiser K, Grozinsi S, et al. Beta-lactam versus beta-lactam-aminoglycoside combination therapy in cancer patients with neutropaenia. Cochrane Database Syst Rev. 2002;(2):CD003038
  6. Barrett TW, Schriger DL. Annals of Emergency Medicine Journal Club (Acutely decompensated heart failure in a county emergency department: a double-blind randomized controlled comparison of nesiritide versus placebo treatment. Answers to May 2008 journal club questions). Ann Emerg Med. 2008;52:458–472
  7. Royston P, Altman DG, Sauerbrei W. Dichotomizing continuous predictors in multiple regression: a bad idea. Stat Med. 2006;25:127–141
  8. Glass GV. Primary, secondary, and meta-analysis of research. Educ Res. 1976;5:3–8
  9. Duff P, Keiser JF. A comparative study of two antibiotic regimens for the treatment of operative site infections. Am J Obstet Gynecol. 1982;142:996–1003
  10. Landau Z, Feld S, Krupsky M. [Ceftriaxone or combined cefazolin-gentamicin for complicated urinary tract infections]. Harefuah. 1990;118:152–153
  11. Barrett TW, Schriger DL. Annals of Emergency Medicine Journal Club (Practical considerations in HIV testing in the emergency department, characteristics of diagnostic tests, and the role of sensitivity analysis in observational studies. Answers to March 2008 Journal Club questions). Ann Emerg Med. 2008;52:170–181
  12. Lang TA, Secic M. How to Report Statistics in Medicine: Annotated Guidelines for Authors, Editors, and Reviewers. 2nd ed.. New York, NY: American College of Physicians; 2006;
  13. Higgins J, Green S Cochrane Collaboration. Cochrane Handbook for Systematic Reviews of Interventions (Cochrane Book Series). Hoboken, NJ: John Wiley & Sons; 2008;

 Editor's Note: You are reading answers to the fifth installment of Annals of Emergency Medicine Journal Club. The questions and the article they are about (Sinert and Bright. Ann Emerg Med. 2008;52:557-560) were published in the November 2008 issue.Information about journal club can be found at http://www.annemergmed.com/content/journalclub.Readers should recognize that these are suggested answers. We hope they are accurate; we know that they are not comprehensive. There are many other points that could be made about these questions or about the article in general. Questions are rated “novice,” () “intermediate,” () and “advanced” () so that individuals planning a journal club can assign the right question to the right student. The “novice” rating does not imply that a novice should be able to spontaneously answer the question. “Novice” means we expect that someone with little background should be able to do a bit of reading, formulate an answer, and teach the material to others. Intermediate and advanced questions also will likely require some reading and research, and that reading will be sufficiently difficult that some background in clinical epidemiology will be helpful in understanding the reading and concepts.We are interested in receiving feedback about this feature. Please e-mail journalclub@acep.org with your comments.

PII: S0196-0644(08)02013-1

doi: 10.1016/j.annemergmed.2008.11.009

Annals of Emergency Medicine
Volume 53, Issue 4 , Pages 536-543 , April 2009

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