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Volume 54, Issue 2 , Pages 158-168.e4 , August 2009

Predictors of Airway and Respiratory Adverse Events With Ketamine Sedation in the Emergency Department: An Individual-Patient Data Meta-analysis of 8,282 Children

Steven M. Green, MD
- Department of Emergency Medicine, Loma Linda University Medical Center and Children's Hospital, Loma Linda, CA
- Address for correspondence: Steven M. Green, MD, Department of Emergency Medicine, Loma Linda University Medical Center, 11234 Anderson St, Loma Linda, CA 92354; 805-969-2144; Fax 775-307-4121
Mark G. Roback, MD
- Department of Pediatrics, University of Minnesota, Minneapolis, MN
Baruch Krauss, MD, EdM
- Division of Emergency Medicine, Children's Hospital and Harvard Medical School, Boston, MA
Lance Brown, MD, MPH
- Department of Emergency Medicine, Loma Linda University Medical Center and Children's Hospital, Loma Linda, CA
Ray G. McGlone, FCEM
- Royal Lancaster Infirmary, Lancaster, UK
Dewesh Agrawal, MD
- Division of Emergency Medicine, Children's National Medical Center, Washington, DC
Michele McKee, MD, MS
- Division of Emergency Medicine, Boston Medical Center, Boston, MA
Markus Weiss, MD
- Department of Anaesthesia, University Children's Hospital, Zurich, Switzerland
Raymond D. Pitetti, MD, MPH
- Division of Pediatric Emergency Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA
Mark A. Hostetler, MD, MPH
- Department of Pediatrics, University of Chicago, Chicago, IL
Joe E. Wathen, MD
- Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO
Greg Treston, MBBS
- Emergency Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia
Barbara M. Garcia Pena, MD
- Division of Emergency Medicine, Miami Children's Hospital, Miami, FL
Andreas C. Gerber, MD
- Department of Anaesthesia, University Children's Hospital, Zurich, Switzerland
Joseph D. Losek, MD
- Department of Pediatrics, Medical University of South Carolina, Charleston, SC
Emergency Department Ketamine Meta-Analysis Study Group
- All members are listed in the Appendix.

Received 23 August 2008 ,Revised 18 November 2008 ,Accepted 9 December 2008.

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Supervising editors: Kathy N. Shaw, MD, MSCE; Michael L. Callaham, MD.

Drs. Shaw and Callaham were the supervising editors on this article. Dr. Green did not participate in the editorial review or decision to publish this article.

Author contributions: SMG conceived and designed the study. The methodology was critiqued and revised with extensive input from MGR, BK, LB, DA, RDP, JEW, and GT. All authors reviewed and recoded their data to comply with study definitions, and before data analysis the study protocol was critiqued and refined by all authors. SMG performed the data analysis, and a writing committee composed of SMG, MGR, and BK then created the article. All authors critiqued the draft, and there were substantial revisions. SMG takes responsibility for the paper as a whole.

Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article that might create any potential conflict of interest. The authors have stated that no such relationships exist. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement.

Earn CME Credit: Continuing Medical Education is available for this article at: www.ACEP-EMedHome.com.

Publication date: Available online February 7, 2009.

Reprints not available from the authors.

PII: S0196-0644(08)02084-2

doi: 10.1016/j.annemergmed.2008.12.011

« Previous Next » Annals of Emergency Medicine
Volume 54, Issue 2 , Pages 158-168.e4 , August 2009