Annals of Emergency Medicine
Volume 55, Issue 5 , Pages 401-407 , May 2010

Randomized, Controlled Trial of Antibiotics in the Management of Community-Acquired Skin Abscesses in the Pediatric Patient

Presented at the Pediatric Academic Society, May 2008, Honolulu, HI; and the Midwest Society of Pediatric Research, October 2008, Cleveland, OH.

  • Myto Duong, MD, MS

      Affiliations

    • Cardinal Glennon Children's Medical Center, Saint Louis University School of Medicine, Pediatric Emergency Medicine Department, Division of Pediatrics, St. Louis, MO
    • Corresponding Author InformationAddress for reprints: Myto Duong, MD, MS, 800 East Carpenter St, St John's Hospital, Emergency Medicine Department, Springfield, IL 62702; 217-757-6510, fax 217-757-6812
    • ,
  • Stephen Markwell, MA

      Affiliations

    • Southern Illinois University, School of Medicine, Division of Statistics and Research Consulting, Springfield, IL
    • ,
  • John Peter, MD

      Affiliations

    • Cardinal Glennon Children's Medical Center, Saint Louis University School of Medicine, Pediatric Emergency Medicine Department, Division of Pediatrics, St. Louis, MO
    • ,
  • Stephen Barenkamp, MD

      Affiliations

    • Cardinal Glennon Children's Medical Center, Saint Louis University School of Medicine, Pediatric Infectious Diseases Division, Department of Pediatrics, Division of Pediatrics, St. Louis, MO

Received 3 November 2008 ,Revised 19 February 2009 ,Accepted 11 March 2009.

References 

  1. Pallin D, Egan J, Pelletier A, et al. Increased US emergency department visits for skin and soft tissue infections, and changes in antibiotic choices, during the emergence of community-associated methicillin-resistant Staphylococcus aureus. Ann Emerg Med. 2008;51:291–298
  2. Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant Staphylococcus aureus infections among patients in the emergency department. N Engl J Med. 2006;355:666–674
  3. Kaplan S. Treatment of community-associated methicillin-resistant Staphylococcus aureus infections. Pediatr Infect Dis. 2005;24:457–445
  4. Fergie J, Purcell K. Community-acquired methicillin-resistant Staphylococcus aureus infections in south Texas children. Pediatr Infect Dis. 2001;20:860–863
  5. Ruhe J, Smith N, Bradsher R, et al. Community onset methicillin-resistant Staphylococcus aureus skin and soft tissue infections: impact of antimicrobial therapy. Clin Infect Dis. 2007;44:777–784
  6. Lee MC, Rios AM, Aten MF, et al. Management and outcome of children with skin and soft tissue abscesses caused by community-acquired methicillin-resistant Staphylococcus aureus. Pediatr Infect Dis. 2004;23:123–127
  7. Young GM. Incision and drainage of a cutaneous abscess. In:  Henretig FM,  King C editor. Textbook of Pediatric Emergency Procedures. Baltimore, MD: Williams & Wilkins; 1997;p. 1199–1204
  8. Llera JL, Levy RC. Treatment of cutaneous abscess: a double-blind clinical study. Ann Emerg Med. 1985;14:15–19
  9. Rajendran P, Young D, Maurer T, et al. Randomized, double-blind, placebo-controlled trial of cephalexin for treatment of uncomplicated skin abscesses in a population at risk of community-acquired methicillin-resistant Staphylococcus aureus infection. Antimicrob Agents Chemother. 2007;55:4044–4048
  10. Wilker MA, Cockerill FR, Craig WA. Performance Standards for Antimicrobial Disk Susceptibility Tests: Approved Standard—9th Edition. Wayne, PA: Clinical and Laboratory Standards Institute; 2006;
  11. Centers for Disease Control and Prevention. Community-associated MRSA information for clinicians: questions and answers. http://www.cdc.gov/ncidod/dhqp/ar_mrsa_ca_clinicians.htmlAccessed March 23, 2009
  12. Chen A, Goldstein M, Carroll K, et al. Evolving epidemiology of pediatric Staphylococcus aureus cutaneous infections in a Baltimore hospital. Pediatr Emerg Care. 2006;22:717–723
  13. Frazee B, Lynn J, Charlebois E, et al. High prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infections. Ann Emerg Med. 2005;45:311–320
  14. Davis S, Perri M, Donabedian S, et al. Epidemiology and outcomes of community-associated methicillin-resistant Staphylococcus aureus infection. J Clin Microbiol. 2007;45:1705–1711

 Supervising editor: Michael W. Shannon, MD; Steven M. Green, MD

 Author contributions: MD was the primary investigator and corresponding author. JP and SB designed the study. JP was involved in patient recruitment. SM conducted statistical analysis and provided graphical assistance. SB provided pediatric infectious disease expertise, with significant input in data analysis and article revision. MD takes responsibility for the paper as a whole.

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article that might create any potential conflict of interest. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. The authors were supported by a Fleur de Lis Award (intramural funding). This clinical trial was registered with the ClinicalTrials.gov Protocol Registration System. The registration/ID number is NCT00679302.

 Dr. Duong is currently affiliated with Southern Illinois University, School of Medicine at St. John's Hospital, Springfield, IL.

 Provide feedback on this article at the journal's Web site, www.annemergmed.com.

 Please see page 402 for the Editor's Capsule Summary of this article.

 Publication date: Available online April 30, 2009.

PII: S0196-0644(09)00270-4

doi: 10.1016/j.annemergmed.2009.03.014

Annals of Emergency Medicine
Volume 55, Issue 5 , Pages 401-407 , May 2010

Article Tools

* Image Usage & Resolution