Annals of Emergency Medicine
Volume 55, Issue 1 , Pages 62-70.e4 , January 2010

Discovery and Validation of Urine Markers of Acute Pediatric Appendicitis Using High-Accuracy Mass Spectrometry

  • Alex Kentsis, MD, PhD

      Affiliations

    • Division of Emergency Medicine, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA
    • Proteomics Center at Children's Hospital Boston, Boston, MA
    • ,
  • Yin Yin Lin, BS

      Affiliations

    • Proteomics Center at Children's Hospital Boston, Boston, MA
    • ,
  • Kyle Kurek, MD

      Affiliations

    • Proteomics Center at Children's Hospital Boston, Boston, MA
    • Department of Pathology, Children's Hospital Boston, Harvard Medical School, Boston, MA
    • ,
  • Monica Calicchio, PhD

      Affiliations

    • Department of Pathology, Children's Hospital Boston, Harvard Medical School, Boston, MA
    • ,
  • Yan Yan Wang, MD

      Affiliations

    • Proteomics Center at Children's Hospital Boston, Boston, MA
    • Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
    • ,
  • Flavio Monigatti, PhD

      Affiliations

    • Proteomics Center at Children's Hospital Boston, Boston, MA
    • Department of Pathology, Children's Hospital Boston, Harvard Medical School, Boston, MA
    • ,
  • Fabien Campagne, PhD

      Affiliations

    • Department of Physiology and Biophysics and HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, NY
    • ,
  • Richard Lee, MD

      Affiliations

    • Proteomics Center at Children's Hospital Boston, Boston, MA
    • ,
  • Bruce Horwitz, MD, PhD

      Affiliations

    • Division of Emergency Medicine, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA
    • Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
    • ,
  • Hanno Steen, PhD

      Affiliations

    • Proteomics Center at Children's Hospital Boston, Boston, MA
    • Department of Pathology, Children's Hospital Boston, Harvard Medical School, Boston, MA
    • ,
  • Richard Bachur, MD

      Affiliations

    • Division of Emergency Medicine, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA
    • Corresponding Author InformationAddress for correspondence: Richard Bachur, MD, 300 Longwood Ave., Boston, MA 02115; 617-355-6624, fax 617-730-0335; or 617-919-2629, fax 617-730-0168

Received 7 January 2009 ,Revised 29 March 2009 ,Accepted 29 April 2009.

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 Supervising editors: Kelly D. Young, MD, MS; Steven M. Green, MD

 Author contributions: AK, HS, and RB were responsible for research design. AK, YYL, MC, YYW, RL, and BH conducted laboratory processing. AK, KK, FM, FC, and BH conducted data analysis. AK, HS, and RB wrote the article. RB takes responsibility for the paper as a whole. HS and RB contributed equally to the article.

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article, that might create any potential conflict of interest. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. Funded in part by the Frederick Lovejoy, Jr, MD Housestaff Research and Education grant, and by Children's Hospital Boston Houseofficer Development Award.

 Publication date: Available online June 25, 2009.

 Reprints not available from the authors.

 Please see page 63 for the Editor's Capsule Summary of this article.

 Provide feedback on this article at the journal's Web site, www.annemergmed.com.

PII: S0196-0644(09)00481-8

doi: 10.1016/j.annemergmed.2009.04.020

Annals of Emergency Medicine
Volume 55, Issue 1 , Pages 62-70.e4 , January 2010

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