Annals of Emergency Medicine
Volume 54, Issue 4 , Pages 568-574 , October 2009

Intravenous Paracetamol or Morphine for the Treatment of Renal Colic: A Randomized, Placebo-Controlled Trial

Presented at the First Eurasian Congress on Emergency Medicine, November 2008, Antalya, Turkey.

  • Firat Bektas, MD

      Affiliations

    • Department of Emergency Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey
    • Corresponding Author InformationAddress for correspondence: Firat Bektas, MD, Department of Emergency Medicine, Akdeniz University Faculty of Medicine, 07059, Antalya, Turkey; 90-242-2496178, fax: 90-242-2274490
    • ,
  • Cenker Eken, MD

      Affiliations

    • Department of Emergency Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey
    • ,
  • Ozgur Karadenız, MD

      Affiliations

    • Department of Emergency Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey
    • ,
  • Erkan Goksu, MD

      Affiliations

    • Department of Emergency Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey
    • ,
  • Metin Cubuk, MD

      Affiliations

    • Department of Radiology, Akdeniz University Faculty of Medicine, Antalya, Turkey
    • ,
  • Yildiray Cete, MD

      Affiliations

    • Department of Emergency Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey

Received 14 October 2008 ,Revised 16 May 2009 ,Accepted 18 June 2009.

References 

  1. Holdgate A, Pollock T. Nonsteroidal anti-inflammatory drugs (NSAIDs) versus opioids for acute renal colic. Cochrane Database Syst Rev. 2004;(1):CD004137
  2. Cordell WH, Larson TA, Lingeman JE, et al. Indomethacin suppositories versus intravenously titrated morphine for the treatment of ureteral colic. Ann Emerg Med. 1994;23:262–269
  3. Larkin GL, Peacock WF, Pearl SM, et al. Efficacy of ketorolac tromethamine versus meperidine in the ED treatment of acute renal colic. Am J Emerg Med. 1999;17:6–10
  4. Safdar B, Degutis LC, Landry K, et al. Intravenous morphine plus ketorolac is superior to either drug alone for treatment of acute renal colic. Ann Emerg Med. 2006;48:173–181
  5. Hyllested M, Jones S, Pedersen JL, et al. Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review. Br J Anaesth. 2002;88:199–214
  6. Moller PL, Juhl GI, Payen-Champenois C, et al. Intravenous acetaminophen (paracetamol): comparable analgesic efficacy, but better local safety than its prodrug, propacetamol, for postoperative pain after third molar surgery. Anesth Analg. 2005;101:90–96
  7. Murat I, Baujard C, Foussat C, et al. Tolerance and analgesic efficacy of a new i.v. paracetamol solution in children after inguinal hernia repair. Paediatr Anaesth. 2005;15:663–670
  8. Sinatra RS, Jahr JS, Reynolds LW, et al. Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery. Anesthesiology. 2005;102:822–831
  9. Van Aken H, Thys L, Veekman L, et al. Assessing analgesia in single and repeated administrations of propacetamol for postoperative pain: comparison with morphine after dental surgery. Anesth Analg. 2004;98:159–165
  10. Cattabriga I, Pacini D, Lamazza G, et al. Intravenous paracetamol as adjunctive treatment for postoperative pain after cardiac surgery: a double blind randomized controlled trial. Eur J Cardiothorac Surg. 2007;32:527–531

 Provide feedback on this article at the journal's Web site, www.annemergmed.com.

 Supervising editor: Knox H. Todd, MD, MPH

 Author contributions: FB and CE conceived the study, designed the trial, and obtained research funding. FB, CE, OK, and EG supervised the conduct of the trial and data collection. FB and CE provided statistical advice on study design and analyzed the data. FB, CE, and YC drafted the article, and all authors contributed substantially to its revision. MC evaluated the Uriner computed tomography. FB takes responsibility for the paper as a whole.

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article that might create any potential conflict of interest. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. This study was supported by the Akdeniz University Research and Project Unit.

 Publication date: Available online July 31, 2009.

 Reprints not available from the authors.

PII: S0196-0644(09)01132-9

doi: 10.1016/j.annemergmed.2009.06.501

Annals of Emergency Medicine
Volume 54, Issue 4 , Pages 568-574 , October 2009

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