Annals of Emergency Medicine
Volume 55, Issue 1 , Pages 40-46.e1 , January 2010

Multicenter Study of Central Venous Oxygen Saturation (ScvO2) as a Predictor of Mortality in Patients With Sepsis

  • Jennifer V. Pope, MD

      Affiliations

    • Harvard Affiliated Emergency Medicine Residency, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    • ,
  • Alan E. Jones, MD

      Affiliations

    • Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC
    • ,
  • David F. Gaieski, MD

      Affiliations

    • Department of Emergency Medicine, Hospital of the University of Pennsylvania, Camden, NJ
    • ,
  • Ryan C. Arnold, MD

      Affiliations

    • Department of Emergency Medicine, Cooper University Hospital, Camden, NJ
    • ,
  • Stephen Trzeciak, MD, MPH

      Affiliations

    • Department of Emergency Medicine, Cooper University Hospital, Camden, NJ
    • Division of Critical Care Medicine, Cooper University Hospital, Camden, NJ
    • ,
  • Nathan I. Shapiro, MD, MPH

      Affiliations

    • Harvard Affiliated Emergency Medicine Residency, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    • Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    • Corresponding Author InformationAddress for correspondence: Nathan I. Shapiro, MD, MPH, Beth Israel Deaconess Medical Center, 1 Deaconess Road, CC2-W, Boston, MA 02215; 617-754-2323, fax 617-754-2350
    • ,
  • Emergency Medicine Shock Research Network (EMShockNet) Investigators

Received 6 February 2009 ,Revised 19 July 2009 ,Accepted 6 August 2009.

References 

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  9. Trzeciak S, McCoy JV, Phillip Dellinger R, et al. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med. 2008;34:2210–2217
  10. Jones AE, Focht A, Horton JM, et al. Prospective external validation of the clinical effectiveness of an emergency department-based early goal directed therapy protocol for severe sepsis and septic shock. Chest. 2007;132:425–432
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  12. Trzeciak S, Dellinger RP, Abate NL, et al. Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department. Chest. 2006;129:225–232
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 Supervising editor: Gregory J. Moran, MD

 Author contributions: All authors participated in the conception of the study, study design, and data collection. JVP and NIS oversaw the final data compilation and statistical analysis. All authors participated in the drafting of the article into its final form. All authors take responsibility for the paper as a whole.

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article that might create any potential conflict of interest. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. This study was supported in part by National Institutes of Health grants HL091757 and GM076659 (Dr. Shapiro), the National Institutes of Health/National Institute of General Medical Sciences: K23GM83211 (Dr. Trzeciak), National Institutes of Health/National Institute of General Medical Sciences: K23GM076652 (Dr. Jones), and a research endowment from the Beatrice Wind Gift Foundation (Dr. Gaieski). Dr. Trzeciak has received research support from Novo Nordisk, Biosite, and Eli Lilly. Dr. Jones has received research support from Critical Biologics and Hutchinson Technology. Dr. Shapiro receives research grants from Hutchinson Technologies, Eli Lilly, and Inverness Medical and is on the Eli Lilly speaker's bureau.

 Reprints not available from the authors.

 Please see page 41 for the Editor's Capsule Summary of this article.

 Provide feedback on this article at the journal's Web site, www.annemergmed.com.

 Publication date: Available online October 25, 2009.

PII: S0196-0644(09)01440-1

doi: 10.1016/j.annemergmed.2009.08.014

Annals of Emergency Medicine
Volume 55, Issue 1 , Pages 40-46.e1 , January 2010

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