Annals of Emergency Medicine
Volume 56, Issue 1 , Pages 1-6 , July 2010

A Prospective, Randomized Trial of Intravenous Prochlorperazine Versus Subcutaneous Sumatriptan in Acute Migraine Therapy in the Emergency Department

Presented at the Society for Academic Emergency Medicine conference, May 2008, Washington, DC.

  • Mark A. Kostic, MD

      Affiliations

    • Department of Emergency Medicine, Naval Medical Center, Portsmouth, VA
    • Department of Pediatrics (Emergency Medicine), Medical College of Wisconsin, Milwaukee, WI
    • Corresponding Author InformationAddress for correspondence: Mark A. Kostic, MD, Medical College of Wisconsin, 999 N 92nd St, Suite C 660, Milwaukee, WI 53226; 414-266-1722, fax: 414-266-6793
    • ,
  • Francisco J. Gutierrez, MD

      Affiliations

    • Department of Emergency Medicine, Naval Medical Center, Portsmouth, VA
    • ,
  • Thomas S. Rieg, PhD

      Affiliations

    • Department of Clinical Investigation and Research, Naval Medical Center, Portsmouth, VA
    • ,
  • Tammy S. Moore, MD

      Affiliations

    • Department of Emergency Medicine, Naval Medical Center, Portsmouth, VA
    • ,
  • Richard T. Gendron, RPh

      Affiliations

    • Department of Pharmacy, Naval Medical Center, Portsmouth, VA

Received 22 December 2008 ,Revised 4 November 2009 ,Accepted 19 November 2009.

References 

  1. Callan JE, Kostic MA, Bachrach EA, et al. Prochlorperazine vs promethazine for headache treatment in the emergency department: a randomized controlled trial. J Emerg Med. 2008;35:247–253
  2. Seim MB, March JA, Dunn KA. Intravenous ketorolac vs intravenous prochlorperazine for the treatment of migraine headaches. Acad Emerg Med. 1998;5:573–576
  3. Tanen DA, Miller S, French T. Intravenous sodium valproate versus prochlorperazine for the emergency department treatment of acute migraine headaches: a prospective, randomized, double-blind trial. Ann Emerg Med. 2003;41:847–853
  4. Brousseau DC, Duffy SJ, Anderson AC, et al. Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac. Ann Emerg Med. 2004;43:256–262
  5. Kabbouche MA, Vockell AB, LeCates SL, et al. Tolerability and effectiveness of prochlorperazine for intractable migraine in children. Pediatrics. 2001;107:e62
  6. Vinson DR, Drotts DL. Diphenhydramine for the prevention of akathisia induced by prochlorperazine: a randomized, controlled trial. J Emerg Med. 2004;26:265–270
  7. Landy S, DeRossett SE, Rapoport A, et al. Two double-blind, multicenter, randomized, placebo-controlled, single-dose studies of sumatriptan/naproxen sodium in the acute treatment of migraine: function, productivity, and satisfaction outcomes. Medscape Gen Med. 2007;9:53
  8. Barbanti P, Le Pera D, Cruccu G. Sumatriptan fast-disintegrating/rapid release tablets in the acute treatment of migraine [review]. Expert Rev Neurother. 2007;7:927–934
  9. Miner JR, Smith SW, Moore J, et al. Sumatriptan for the treatment of undifferentiated primary headaches in the ED. Am J Emerg Med. 2007;25:60–64
  10. Tfelt-Hanson P, Bach FW, Daugaard D, et al. Treatment with sumatriptan 50 mg in the mild phase of migraine attacks in patients with infrequent attacks: a randomised, double-blind, placebo-controlled study. J Headache Pain. 2006;7:389–394
  11. Cady R, Schreiber C. Sumatriptan: update and review [review]. Expert Opin Pharmacother. 2006;7:1503–1514
  12. Friedman BW, Corbo J, Lipton RB, et al. A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines. Neurology. 2005;64:463–468
  13. Sandrini G, Cerbo R, Del Bene E, et al. Efficacy of dosing and re-dosing of two oral fixed combinations of indomethacin, prochlorperazine, and caffeine compared with oral sumatriptan in the acute treatment of multiple migraine attacks: a double-blind, double-dummy, randomised, parallel group, multicentre study. Int J Clin Pract. 2007;61:1256–1269
  14. Gillian CH, Brown MM, Mo J, et al. Triptans in migraine: the risks of stroke, cardiovascular disease, and death in practice. Neurology. 2004;62:563–568
  15. Mathew NT, Loder EW. Evaluating the triptans. Am J Med. 2005;118(suppl 1):28S–35S
  16. Donohue C, Thomas SH, Benson CK. Prochlorperazine versus sumatriptan for emergency department therapy of migraine headache. Ann Emerg Med. 1995;25:154–155
  17. Goldstein J, Camargo CA, Pelletier J, et al. Headache in United States emergency departments: demography, work up and frequency of pathological diagnoses. Cephalalgia. 2006;26:684–690
  18. Vinson DR. Treatment patterns of isolated benign headache in US emergency departments. Ann Emerg Med. 2002;39:215–222
  19. Todd KH, Funk KG, Funk JP, et al. Clinical significance of reported changes in pain severity. Ann Emerg Med. 1996;27:485–489
  20. Gallagher EJ, Liebman M, Bijur PE. Prospective evaluation of clinically important changes in pain severity measured on a visual analog scale. Ann Emerg Med. 2001;38:633–638
  21. Burstein R, Cutrer MF, Yarnitsky D. The development of cutaneous allodynia during a migraine attack: clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain. 2000;123:1703–1709
  22. Peroutka S. Dopamine and migraine. Neurology. 1997;49:650–656
  23. Kelly A, Ardagh M, Curry C, et al. Intravenous chlorpromazine versus intramuscular sumatriptan for acute migraine. J Accid Emerg Med. 1997;14:209–211
  24. Goadsby PJ, Lipton RB, Ferrari MD. Migraine: current understanding and treatment. N Engl J Med. 2002;346:257–270
  25. van Zanten ARH, Engelfriet PM, van Dillen K, et al. Importance of nondrug costs of intravenous antibiotic therapy. Crit Care. 2003;7:184–190

 See page 2 for the Editor's Capsule Summary of this article.

 Provide feedback on this article at the journal's Web site, www.annemergmed.com.

 Supervising editor: Knox H. Todd, MD, MPH

 Author contributions: MAK was the faculty advisor, conceived the study and design, edited institutional review board proposal, supervised logistics, and wrote the article. FJG, TSM, and RTG assisted with study design. FJG and TSM assisted with logistics and follow-up. FJG prepared the study for the institutional review board and was in charge of data collection. TSR performed all statistical calculations and assisted with article preparation. RTG performed randomization, prepared all drug packets, and kept the master list linking subjects with study packets. MAK takes responsibility for the paper as a whole.

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article that might create any potential conflict of interest. The authors have stated that no such relationships exist. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement.

 Publication date: Available online January 4, 2010.

 Reprints not available from the authors.

PII: S0196-0644(09)01794-6

doi: 10.1016/j.annemergmed.2009.11.020

Annals of Emergency Medicine
Volume 56, Issue 1 , Pages 1-6 , July 2010

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