Annals of Emergency Medicine
Volume 56, Issue 5 , Pages 571-577.e1 , November 2010

Immediate β-Blockade in Patients With Myocardial Infarctions: Is There Evidence of Benefit?

  • Richard Sinert, DO

      Affiliations

    • Department of Emergency Medicine, SUNY–Downstate Medical Center, Brooklyn, NY
    • Corresponding Author InformationAddress for correspondence: Richard Sinert, DO, Department of Emergency Medicine, Box 1228, SUNY–Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203; 718-245-2973, fax 718-245-4799
    • ,
  • David H. Newman, MD

      Affiliations

    • Columbia University, Department of Emergency Medicine, St. Luke's–Roosevelt Hospital Center, New York, NY
    • ,
  • Ethan Brandler, MD

      Affiliations

    • Department of Emergency Medicine, SUNY–Downstate Medical Center, Brooklyn, NY
    • ,
  • Lorenzo Paladino, MD

      Affiliations

    • Department of Emergency Medicine, SUNY–Downstate Medical Center, Brooklyn, NY

References 

  1. Perez MI, Musini VM, Wright JM. Effect of early treatment with anti-hypertensive drugs on short and long-term mortality in patients with an acute cardiovascular event. Cochrane Database Syst Rev. 2009;(4):CD006743
  2. Ellison KE, Gandhi G. Optimising the use of beta-adrenoceptor antagonists in coronary artery disease. Drugs. 2005;65:787–797
  3. The β-Blocker Heart Attack Trial Research Group. A randomized trial of propranolol in patients with acute myocardial infarction (I. Mortality results). JAMA. 1982;247:1707–1714
  4. Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. N Engl J Med. 1981;304:801–807
  5. First International Study of Infarct Survival Collaborative Group. Randomised trial of intravenous atenolol among 16,027 cases of suspected acute myocardial infarction: ISIS-1. Lancet. 1986;2:57–66
  6. Chen ZM, Pan HC, Chen YP, et al. Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet. 2005;366:1622–1632
  7. Roberts R, Rogers WJ, Mueller HS, et al. Immediate versus deferred beta-blockade following thrombolytic therapy in patients with acute myocardial infarction (Results of the Thrombolysis in Myocardial Infarction (TIMI) II-B Study). Circulation. 1991;83:422–437
  8. Ryan TJ, Anderson JL, Antman EM, et al. ACC/AHA guidelines for the management of patients with acute myocardial infarction (A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines). (Committee on Management of Acute Myocardial Infarction) J Am Coll Cardiol. 1996;28:1328–1428
  9. Ryan T, Antman EM, Brooks NH, et al. 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction (A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines). (Committee on Management of Acute Myocardial Infarction) J Am Coll Cardiol. 1999;34:890–911
  10. Antman EM, Anbe DT, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction—executive summary (A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines). (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction) J Am Coll Cardiol. 2004;44:671–719
  11. Antman EM, Anbe DT, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. (Committee to Revise the 1999 Guidelines for the Management of patients With Acute Myocardial Infarction) J Am Coll Cardiol. 2004;44:E1–E211
  12. Antman EM, Anbe DT, Armstrong PW, et al. http://www.cms.hhs.gov/HospitalQualityInits/downloads/HospitalAMI-6FactSheet.pdf2008-12-31. Accessed January 6, 2009
  13. Perez MI, Musini VM, Wright JM, et al. Effect of early treatment with anti-hypertensive drugs on short and long-term mortality in patients with an acute cardiovascular event. Cochrane Database Syst Rev. 2009;(4):CD006743

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article that might create any potential conflict of interest. The authors have stated that no such relationships exist. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement.

 Reprints not available from the authors.

PII: S0196-0644(10)00341-0

doi: 10.1016/j.annemergmed.2010.03.036

Annals of Emergency Medicine
Volume 56, Issue 5 , Pages 571-577.e1 , November 2010

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