Annals of Emergency Medicine
Volume 59, Issue 2 , Pages 115-125.e1 , February 2012

Development of a Clinical Prediction Rule for 30-Day Cardiac Events in Emergency Department Patients With Chest Pain and Possible Acute Coronary Syndrome

  • Erik P. Hess, MD, MSc

      Affiliations

    • Department of Emergency Medicine, Division of Emergency Medicine Research, Mayo Clinic College of Medicine, Rochester, MN
    • Knowledge and Evaluation Research Unit, Rochester, MN
    • Corresponding Author InformationAddress for correspondence: Erik P. Hess, MD, MSc
    • ,
  • Robert J. Brison, MD

      Affiliations

    • Department of Emergency Medicine, Queens University, Kingston, Ontario, Canada
    • ,
  • Jeffrey J. Perry, MD, MSc

      Affiliations

    • Department of Emergency Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Lisa A. Calder, MD, MSc

      Affiliations

    • Department of Emergency Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Venkatesh Thiruganasambandamoorthy, MD, MSc

      Affiliations

    • Department of Emergency Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Dipti Agarwal, MBBS

      Affiliations

    • Department of Emergency Medicine, Division of Emergency Medicine Research, Mayo Clinic College of Medicine, Rochester, MN
    • ,
  • Annie T. Sadosty, MD

      Affiliations

    • Department of Emergency Medicine, Division of Emergency Medicine Research, Mayo Clinic College of Medicine, Rochester, MN
    • ,
  • Marco L.A. Silvilotti, MD, MSc

      Affiliations

    • Department of Emergency Medicine, Queens University, Kingston, Ontario, Canada
    • ,
  • Allan S. Jaffe, MD

      Affiliations

    • Department of Internal Medicine, Division of Cardiology, Mayo Clinic College of Medicine, Rochester, MN
    • ,
  • Victor M. Montori, MD, MSc

      Affiliations

    • Division of Endocrinology and Nutrition, Mayo Clinic College of Medicine, Rochester, MN
    • Knowledge and Evaluation Research Unit, Rochester, MN
    • ,
  • George A. Wells, PhD

      Affiliations

    • Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • ,
  • Ian G. Stiell, MD, MSc

      Affiliations

    • Department of Emergency Medicine, University of Ottawa, Ottawa, Ontario, Canada
    • Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada

Received 29 April 2011 ,Revised 5 July 2011 ,Accepted 13 July 2011.

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 Supervising editor: Judd E. Hollander, MD

 Author contributions: All authors contributed significantly to the study and the preparation of the article. EPH, JJP, ASJ, GAW, and IGS were responsible for the conception and design of the study. LAC, VT, DA, and ATS assisted with data acquisition. EPH and RJB were responsible for data acquisition, data entry, and preliminary analysis. EPH and GAW performed all statistical analyses. All authors participated in the drafting and multiple revisions of the article and gave final approval of the submitted work. EPH takes responsibility for the paper as a whole.

 Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The study was funded by a Fellow-to-Faculty Transition award from the American Heart Association, the Society for Academic Emergency Medicine, and the Emergency Medicine Foundation (award 0775030N). The study was also supported by the Ontario Innovation Fund and the University of Ottawa Department of Emergency Medicine.

 Provide feedback on this article at the journal's Web site, www.annemergmed.com.

 A podcast for this article is available at www.annemergmed.com.

 Please see page 116 for the Editor's Capsule Summary of this article.

 Earn CME Credit: Continuing Medical Education is available for this article at http://www.ACEP-EMedHome.com.

 Publication date: Available online September 1, 2011.

PII: S0196-0644(11)01343-6

doi: 10.1016/j.annemergmed.2011.07.026

Annals of Emergency Medicine
Volume 59, Issue 2 , Pages 115-125.e1 , February 2012

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