Annals of Emergency Medicine
Volume 28, Issue 5 , Pages 549-551, November 1996

Late Increase in Acetaminophen Concentration After Overdose of Tylenol Extended Relief☆☆☆★

Presented at the North American Congress of Clinical Toxicology, Rochester, New York, September 1995.

Received 27 December 1995; received in revised form 15 May 1996; accepted 25 June 1996.

Abstract 

We report a case demonstrating a late increase in acetaminophen concentration after ingestion of Tylenol Extended Relief (extended-release acetaminophen; McNeil Consumer Products) along with drugs known to slow gastrointestinal motility. Coingestants that slow gastrointestinal motility are known to affect the interpretation of serum drug concentrations. However, this case illustrates potentially significant differences between extended-release and immediate-release acetaminophen and demonstrates an exception to the current manufacturer recommendation for the use of the Rumack-Matthew nomogram in this setting. [Bizovi KE, Aks SE, Paloucek F, Gross R, Keys N, Rivas J: Late increase in acetaminophen concentration after overdose of Tylenol Extended Relief. Ann Emerg Med November 1996;28: 549-551.]

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☆ From the Toxikon Consortium (Cook County Hospital, University of Illinois, Rush-Presbyterian-St Luke's Medical Center)*; the Department of Emergency Medicine, Mercy Hospital and Medical Center‡; the University of Illinois Program in Emergency Medicine§; the Department of Pharmacy Practice, College of Pharmacy, University of Illinois∥; and the Department of Emergency Medicine, Northwestern Memorial Hospital, Chicago Illinois.

☆☆ Address for reprints: Steven Aks, DO, Department of Emergency Medicine, Mercy Hospital and Medical Center, Stevenson Expressway at King Drive, Chicago, Illinois 60616, 312-567-2150, Fax 312 567-2410, E-mail saks@uic.edu

★ Reprint no. 47/1/76687

PII: S0196-0644(96)70119-1

Annals of Emergency Medicine
Volume 28, Issue 5 , Pages 549-551, November 1996

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