Advertisement

Is High-Flow Nasal Cannula More Effective Than Conventional Oxygen Therapy for Preventing Escalation of Respiratory Support in Patients With Acute Respiratory Failure?

      High-flow nasal cannula and conventional oxygen therapy demonstrate similar results in the treatment of acute respiratory failure in regard to rates of respiratory support escalation, intubation, mortality, and ICU transfer, although it may decrease the need for escalation of respiratory support and intubation among patients with acute respiratory failure who are undergoing treatment for greater than or equal to 24 hours.
      To read this article in full you will need to make a payment
      ACEP Member Login
      ACEP Members, full access to the journal is a member benefit. Use your society credentials to access all journal content and features.

      Purchase one-time access:

      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Higgins J.
        • Green S.
        Cochrane Handbook for Systematic Reviews of Interventions.
        Cochrane Collaboration, 2011 (Version 5.1.0 [updated March 2011]. Available at:) (Accessed February 2, 2018)
        • Jones P.G.
        • Kamona S.
        • Doran O.
        • et al.
        Randomized controlled trial of humidified high-flow nasal oxygen for acute respiratory distress in the emergency department: the HOT-ER study.
        Respir Care. 2016; 61: 291-299
        • Frat J.P.
        • Thille A.W.
        • Mercat A.
        • et al.
        High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure.
        N Engl J Med. 2015; 372: 2185-2196
        • Bell N.
        • Hutchinson C.L.
        • Green T.C.
        • et al.
        Randomised control trial of humidified high flow nasal cannulae versus standard oxygen in the emergency department.
        Emerg Med Australas. 2015; 27: 537-541
        • Lemiale V.
        • Djamel M.
        • Julien M.
        • et al.
        The effects of a 2-h trial of high-flow oxygen by nasal cannula versus Venturi mask in immunocompromised patients with hypoxemic acute respiratory failure: a multicenter randomized trial.
        Crit Care. 2015; 19: 380
        • Roca O.
        • Riera J.
        • Torres F.
        • et al.
        High-flow oxygen therapy in acute respiratory failure.
        Respir Care. 2010; 55: 408-413
        • Parke R.
        • McGuinness S.
        • Eccleston M.
        Nasal high-flow therapy delivers low level positive airway pressure.
        Br J Anaesth. 2009; 103: 886-890
        • Parke R.L.
        • McGuinness S.P.
        Pressures delivered by nasal high flow oxygen during all phases of the respiratory cycle.
        Respir Care. 2013; 58: 1621-1624
        • Roca O.
        • Gonzalo H.
        • Salvador D.L.
        • et al.
        Current evidence for the effectiveness of heated and humidified high flow nasal cannula supportive therapy in adult patients with respiratory failure.
        Crit Care. 2016; 20: 109
        • Monro-Somerville T.
        • Sim M.
        • Ruddy J.
        • et al.
        The effect of high-flow nasal cannula oxygen therapy on mortality and intubation rate in acute respiratory failure: a systematic review and meta-analysis.
        Crit Care Med. 2017; 45: e449-e456