- Cochrane Handbook for Systematic Reviews of Interventions.Cochrane Collaboration, 2011 (Version 5.1.0 [updated March 2011]. Available at:)Accessed February 2, 2018)
- Randomized controlled trial of humidified high-flow nasal oxygen for acute respiratory distress in the emergency department: the HOT-ER study.Respir Care. 2016; 61: 291-299
- High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure.N Engl J Med. 2015; 372: 2185-2196
- Randomised control trial of humidified high flow nasal cannulae versus standard oxygen in the emergency department.Emerg Med Australas. 2015; 27: 537-541
- The effects of a 2-h trial of high-flow oxygen by nasal cannula versus Venturi mask in immunocompromised patients with hypoxemic acute respiratory failure: a multicenter randomized trial.Crit Care. 2015; 19: 380
- High-flow oxygen therapy in acute respiratory failure.Respir Care. 2010; 55: 408-413
- Nasal high-flow therapy delivers low level positive airway pressure.Br J Anaesth. 2009; 103: 886-890
- Pressures delivered by nasal high flow oxygen during all phases of the respiratory cycle.Respir Care. 2013; 58: 1621-1624
- Current evidence for the effectiveness of heated and humidified high flow nasal cannula supportive therapy in adult patients with respiratory failure.Crit Care. 2016; 20: 109
- The effect of high-flow nasal cannula oxygen therapy on mortality and intubation rate in acute respiratory failure: a systematic review and meta-analysis.Crit Care Med. 2017; 45: e449-e456
Editor’s Note: This is a clinical synopsis, a regular feature of the Annals' Systematic Review Snapshot (SRS) series. The source for this systematic review snapshot is: Zhu Y, Yin H, Zhang R, et al. High-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients with acute respiratory failure: a systematic review and meta-analysis of randomized controlled trials. BMC Pulm Med. 2017;17:201.
This review does not reflect the views or opinions of the US government, Department of Defense or its components, US Army, US Air Force, or SAUSHEC EM Residency Program.
Michael Brown, MD, MSc, Jestin N. Carlson, MD, MS, and Alan Jones, MD, serve as editors of the SRS series.