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Please see page 36 for the Editor’s Capsule Summary of this article.
Supervising editor: Timothy F. Platts-Mills, MD, MSc. Specific detailed information about possible conflict of interest for individual editors is available at https://www.annemergmed.com/editors.
Author contributions: KG, CLA, BB, SLM, JT, and KdW conceptualized the study. KG, CLA, RS, and KdW developed the data creation plan and analysis plan. KE conducted the analysis. CT conducted the validation study. All authors contributed to data interpretation. KG, KdW, and DH created the first draft of the manuscript, and all authors provided critical feedback and edits for the final manuscript. KG takes responsibility for the integrity of the work as a whole.
All authors attest to meeting the four ICMJE.org authorship criteria: (1) Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; AND (2) Drafting the work or revising it critically for important intellectual content; AND (3) Final approval of the version to be published; AND (4) Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (seewww.icmje.org). This study received funding support from a CanVECTOR Research Start-Up Award. Dr Grewal was supported by a CanVECTOR fellowship award; the CanVECTOR Network receives grant funding from the Canadian Institutes of Health Research (Funding Reference: CDT-142654 ). The funding agreement ensured the investigators maintained control over the study design, methods, and interpretation of the results. Dr Atzema was supported by a Mid-Career Investigator Awards from the Heart and Stroke Foundation , Sunnybrook Health Sciences Centre, and ICES . Dr de Wit was supported by grants from Hamilton Health Sciences Foundation and the PSI Foundation .
This study was supported by ICES, which is funded by an annual grant from the Ontario Ministry of Health (MOH) and the Ministry of Long-Term Care (MLTC). Parts of this material are based on data and information compiled and provided by the MOH, MLTC, Canadian Institute for Health Information (CIHI), and Cancer Care Ontario (CCO). The analyses, conclusions, opinions, and statements expressed herein are solely those of the authors and do not reflect those of the funding or data sources; no endorsement is intended or should be inferred. We thank IQVIA Solutions Canada Inc for use of their Drug Information File.
The data set from this study is held securely in coded form at ICES. While data sharing agreements prohibit ICES from making the data set publicly available, access may be granted to those who meet prespecified criteria for confidential access, available at www.ices.on.ca/DAS. The full data set creation plan and underlying analytic code are available from the authors on request, understanding that the computer programs may rely on coding templates or macros that are unique to ICES and therefore are inaccessible or may require modification.
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